IGF2R/M6PR Antibody (2G11): sc-53146

IGF-IIR Antibody (2G11) is a mouse monoclonal IgG2a kappa light chain antibody that detects IGF-IIR of human and bovine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). IGF-IIR, also known as the mannose 6-phosphate/insulin-like growth factor II receptor, is a crucial integral glycoprotein that plays a significant role in cellular processes. IGF-IIR is primarily located in the cell membrane, where IGF-IIR functions as a receptor that binds glycoproteins through extracytoplasmic domains. This binding is essential for mediating the activation of transforming growth factor beta 1 (TGFβ1), which acts as a growth inhibitor, as well as for the degradation of insulin-like growth factor II (IGF-II) and the transport of lysosomal enzymes. IGF-IIR′s ability to form oligomeric complexes enhances affinity for lysosomal enzymes, thereby facilitating their transport and function. Unlike IGF-IR, IGF-IIR does not promote the signaling pathways associated with IGF-I or IGF-II, which are known for their mitogenic and cell survival effects, thus positioning IGF-IIR as a tumor suppressor. IGF-IIR gene is situated on chromosome 6q26, a region frequently implicated in mutations or deletions associated with various human cancers, underscoring IGF-IIR′s importance in cancer biology and therapeutic research.

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IGF2R/M6PR Antibody (2G11) References:

1. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation.  |  Huang, CY., et al. 2014. Cell Death Differ. 21: 1262-74. PMID: 24786827
2. HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy.  |  Huang, CY., et al. 2018. J Cell Physiol. 233: 979-989. PMID: 28383811
3. Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression.  |  Lin, YC., et al. 2017. J Ethnopharmacol. 205: 41-50. PMID: 28473244
4. Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy.  |  Huang, CY., et al. 2018. Int J Cardiol. 257: 283-290. PMID: 29180262
5. Rab9-dependent autophagy is required for the IGF-IIR triggering mitophagy to eliminate damaged mitochondria.  |  Huang, CY., et al. 2018. J Cell Physiol. 233: 7080-7091. PMID: 29574782
6. β-catenin/LEF1/IGF-IIR Signaling Axis Galvanizes the Angiotensin-II- induced Cardiac Hypertrophy.  |  Lai, CH., et al. 2019. Int J Mol Sci. 20: PMID: 31480672
7. The combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.  |  Chen, CH., et al. 2020. J Cell Physiol. 235: 3539-3547. PMID: 31584202
8. LPS-enhanced IGF-IIR pathway to induce H9c2 cardiomyoblast cell hypertrophy was attenuated by Carthamus tinctorius extract via IGF-IR activation.  |  Tung, CL., et al. 2020. Environ Toxicol. 35: 145-151. PMID: 31714667
9. Ohwia caudata inhibits doxorubicin-induced cardiotoxicity by regulating mitochondrial dynamics via the IGF-IIR/p-Drp1/PARP signaling pathway.  |  Chen, JK., et al. 2024. Biotechnol Appl Biochem. 71: 1181-1194. PMID: 38837810
10. Developmental expression of insulin-like growth factor II receptor (IGF-IIR) in congenic mouse embryonic lungs: correlation between IGF-IIR mRNA and protein levels and heterochronic lung development.  |  Melnick, M., et al. 1996. Mol Reprod Dev. 44: 159-70. PMID: 9115713

The preferred IGF2R/M6PR antibody is IGF2R/M6PR Antibody (29): sc-136321.