Ig λ chain Antibody (A-3): sc-166295

Ig λ chain Antibody (A-3) is a mouse monoclonal IgG1 light chain antibody that detects Ig λ chain in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Ig λ chain antibody (A-3) plays a crucial role in the immune response by recognizing and binding to specific antigens, which is essential for the activation of various immune pathways. Ig λ chain is one of the two types of light chains found in immunoglobulins, and its presence is vital for the proper assembly and function of antibodies. Located in the cytoplasm of B cells, Ig λ chain combines with heavy chains to form functional antibodies, which are key players in the adaptive immune system. The ability of Ig λ chain to pair with different heavy chains allows for a diverse range of antibodies, enabling the immune system to respond effectively to a wide variety of pathogens. Additionally, Ig λ chain can undergo post-translational modifications, such as glycosylation, which can influence stability, distribution, and interaction with other proteins, further underscoring importance in immune function. With specificity and versatility, Ig λ chain (A-3) antibody is an invaluable tool for researchers studying immune responses and antibody production in human samples.

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Ig λ chain Antibody (A-3) References:

1. Immunoglobulin lambda chain gene rearrangement in a case of acute nonlymphoblastic leukemia.  |  Sánchez-García, I., et al. 1999. Leukemia. 13: 485-7. PMID: 10086742
2. Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.  |  Derudder, E., et al. 2009. Nat Immunol. 10: 647-54. PMID: 19412180
3. Organization and genomic complexity of sheep immunoglobulin light chain gene loci.  |  Qin, T., et al. 2015. Immunol Lett. 168: 313-8. PMID: 26499865
4. TAK1 maintains the survival of immunoglobulin λ-chain-positive B cells.  |  Shinohara, H., et al. 2016. Genes Cells. 21: 1233-1243. PMID: 27696624
5. Complementary DNA for a human subgroup IV immunoglobulin lambda-chain.  |  Yamasaki, N., et al. 1987. Mol Immunol. 24: 981-5. PMID: 2889139
6. Identification of clonal immunoglobulin λ light-chain gene rearrangements in AL amyloidosis using next-generation sequencing.  |  Kimura, K., et al. 2021. Exp Hematol. 101-102: 34-41.e4. PMID: 34411686
7. Characterization of the immunoglobulin lambda chain locus from diverse populations reveals extensive genetic variation.  |  Gibson, WS., et al. 2023. Genes Immun. 24: 21-31. PMID: 36539592
8. Molecular cloning of a human immunoglobulin lambda chain variable sequence.  |  Tsujimoto, Y. and Croce, CM. 1984. Nucleic Acids Res. 12: 8407-14. PMID: 6095199
9. Characterization of a variable fragment of a human immunoglobulin lambda chain obtained by peptic cleavage in urea.  |  Imbe, M. and Matsumoto, H. 1983. Biochem Biophys Res Commun. 111: 89-95. PMID: 6403015
10. The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.  |  Gorman, JR., et al. 1996. Immunity. 5: 241-52. PMID: 8808679

The preferred Ig λ chain antibody is Ig λ chain Antibody (N10/2): sc-53344.