Ig κ chain Antibody (OX12): sc-53079
- Ig κ chain Antibody (OX12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against F(ab')2 fragment of IgG of rat origin
- recommended for detection of a determinant on rat κ chains of mouse and rat origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Ig κ chain Antibody (OX12). These reagents are now offered in bundles with Ig κ chain Antibody (OX12) (see ordering information below).
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SEE ALSO...
Ig κ chain Antibody (OX12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Ig κ chain protein of mouse and rat origin by immunofluorescence (IF) and flow cytometry (FCM). Ig κ chain plays a crucial role in immune response, as one of two types of light chains that pair with heavy chains to form functional antibodies. The presence of κ light chain is essential for proper assembly and stability of immunoglobulins, which are vital for recognizing and neutralizing pathogens. In B cell development, rearrangement of immunoglobulin genes allows for a diverse repertoire of antibodies, enabling immune systems to respond effectively to a wide range of antigens. Ig κ chain is encoded by genes located on chromosome 2 in humans, and expression is tightly regulated during B cell maturation, ensuring each B cell produces a unique antibody specific to a particular antigen. Understanding Ig κ chain function and significance is important for research into immune responses and development of therapeutic antibodies. Anti-Ig κ chain antibody (OX12) serves as an invaluable tool for researchers studying these processes in mouse and rat models.
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Ig κ chain Antibody (OX12) References:
- Detection of immunoglobulin kappa light chain rearrangements by polymerase chain reaction. An improved method for detecting clonal B-cell lymphoproliferative disorders. | Gong, JZ., et al. 1999. Am J Pathol. 155: 355-63. PMID: 10433929
- Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain. | Jones, D., et al. 1999. Hum Pathol. 30: 1441-8. PMID: 10667422
- Delayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein. | Xu, S. and Lam, KP. 2002. J Exp Med. 196: 197-206. PMID: 12119344
- Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells. | Li, M., et al. 2004. Int J Biochem Cell Biol. 36: 2250-7. PMID: 15313470
- Russell body duodenitis with immunoglobulin kappa light chain restriction. | Munday, WR., et al. 2015. World J Gastrointest Endosc. 7: 73-6. PMID: 25610537
- Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro. | Mizushima-Sugano, J. and Roeder, RG. 1986. Proc Natl Acad Sci U S A. 83: 8511-5. PMID: 3095838
- Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice. | Kofler, R., et al. 1988. J Clin Invest. 82: 852-60. PMID: 3138286
- cDNA clone encoding a complete rabbit immunoglobulin kappa light chain of b4 allotype. | Dreher, KL., et al. 1983. Proc Natl Acad Sci U S A. 80: 4489-93. PMID: 6410392
- c-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations. | Rappold, GA., et al. 1984. EMBO J. 3: 2951-5. PMID: 6441706
- Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization. | Malcolm, S., et al. 1982. Proc Natl Acad Sci U S A. 79: 4957-61. PMID: 6812058
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ig κ chain Antibody (OX12) | sc-53079 | 200 µg/ml | $316.00 | |||
Ig κ chain Antibody (OX12): m-IgG Fc BP-HRP Bundle | sc-536886 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ig κ chain Antibody (OX12): m-IgGκ BP-HRP Bundle | sc-534057 | 200 µg Ab; 40 µg BP | $354.00 | |||
Ig κ chain Antibody (OX12): m-IgG2a BP-HRP Bundle | sc-547892 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ig κ chain Antibody (OX12) FITC | sc-53079 FITC | 200 µg/ml | $330.00 | |||
Ig κ chain Antibody (OX12) PE | sc-53079 PE | 200 µg/ml | $343.00 |