IFN-γ/Interferon gamma Antibody (A35): sc-52555
- IFN-γ/Interferon gamma Antibody (A35) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against recombinant IFN-γ of human origin
- recommended for detection of IFN-γ of human origin by ELISA
- See IFN-γ/Interferon gamma (E-10): sc-373727 for IFN-γ/Interferon gamma antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (A35). This work is in progress.
IFN-γ Antibody (A35) is a mouse monoclonal IgG1 antibody that detects Interferon (IFN)-γ in human samples through enzyme-linked immunosorbent assay (ELISA). IFN-γ plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Anti-IFN-γ antibody (A35) helps study IFN-γ′s ability to modulate T cell growth and differentiation while inhibiting B cell proliferation, orchestrating a balanced immune response. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the helices′ interface. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and functionality is further enhanced by various post-translational modifications, including glycosylation, which can lead to the formation of multiple isoforms under non-denaturing conditions. These isoforms, including dimers and tetramers, are essential for IFN-γ′s biological activity and stability, making IFN-γ monoclonal antibody (A35) a valuable tool for studying immune responses and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFN-γ/Interferon gamma Antibody (A35) References:
- Stabilization of aerosolized IFN-gamma by liposomes. | Kanaoka, E., et al. 1999. Int J Pharm. 188: 165-72. PMID: 10518672
- Self-limitation of Th1-mediated inflammation by IFN-gamma. | Feuerer, M., et al. 2006. J Immunol. 176: 2857-63. PMID: 16493042
- IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure. | Li, ZY., et al. 2015. Sci Rep. 5: 18159. PMID: 26655673
- IFN-γ Primes Keratinocytes for HSV-1-Induced Inflammasome Activation. | Strittmatter, GE., et al. 2016. J Invest Dermatol. 136: 610-620. PMID: 26739094
- Surfactant Protein A Prevents IFN-γ/IFN-γ Receptor Interaction and Attenuates Classical Activation of Human Alveolar Macrophages. | Minutti, CM., et al. 2016. J Immunol. 197: 590-8. PMID: 27271568
- IFN-γ in tissue-immune homeostasis and antitumor immunity. | Kwon, B. 2018. Cell Mol Immunol. 15: 531-532. PMID: 28967878
- Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration. | Strickland, MR., et al. 2018. Neurobiol Dis. 110: 133-141. PMID: 29196213
- Immune Response and Mechanisms of IFN-γ in Administration for Keratomycosis. | Zheng, X., et al. 2019. Ocul Immunol Inflamm. 27: 958-967. PMID: 30307777
- Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ. | Tsumura, M., et al. 2022. J Allergy Clin Immunol. 149: 252-261.e6. PMID: 34176646
- Pulmonary IFN-γ Causes Lymphocytic Inflammation and Cough Hypersensitivity by Increasing the Number of IFN-γ-Secreting T Lymphocytes. | Deng, Z., et al. 2022. Allergy Asthma Immunol Res. 14: 653-673. PMID: 36426396
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (A35) | sc-52555 | 100 µg/ml | $322.00 |