IFN-αR1 Antibody (MAR1-1H5): sc-53590

IFN-αR1 Antibody (MAR1-1H5) is a mouse monoclonal IgG1 antibody that detects IFN-αR1 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). IFN-αR1 plays a crucial role in the immune response by serving as a receptor for type I interferons, specifically IFN-α and IFN-β, which are vital for establishing an antiviral state in cells. The presence of IFN-αR1 on the cell surface allows for the binding of these interferons, triggering a cascade of intracellular signaling that activates immune responses and enhances the ability of cells to combat viral infections. Notably, IFN-αR1 exists in two forms: the full-length chain (IFN-αR1a) and a splice variant (IFN-αR1), which can influence receptor functionality and responsiveness to interferons. The interaction of IFN-αR1 with cytoplasmic tyrosine kinase JAK1 is essential for effective signal transduction, highlighting this receptor′s importance in mediating biological effects of type I interferons. Anti-IFN-αR1 antibody (MAR1-1H5) enables researchers to gain insights into immune signaling mechanisms and interferon roles in antiviral defense, making this tool valuable for studies in immunology and virology.

The preferred IFN-αR1 antibody is IFN-αR1 Antibody (MAR1-5A3): sc-53591.