IFIT2 Antibody (G-9): sc-398610
- IFIT2 Antibody (G-9) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 23-78 mapping near the N-terminus of IFIT2 of mouse origin
- IFIT2 Antibody (G-9) is recommended for detection of IFIT2 of mouse origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IFIT2 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IFIT2 Antibody (G-9) for WB and IHC(P) applications. These reagents are now offered in bundles with IFIT2 Antibody (G-9) (see ordering information below).
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IFIT2 Antibody (G-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects IFIT2 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IFIT2 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. IFIT2, also known as interferon-induced protein with tetratricopeptide repeats 2, is a 472 amino acid protein characterized by six tetratricopeptide repeat (TPR) motifs, which are crucial for mediating protein-protein interactions. These TPR motifs, consisting of a degenerate 34 amino acid sequence, facilitate the assembly of protein complexes that play significant roles in various cellular pathways, including the regulation of immune responses and cell growth. IFIT2′s ability to interact with other proteins is vital for negative regulation of cell proliferation, making IFIT2 an important player in maintaining cellular homeostasis. The gene encoding IFIT2 is located on human chromosome 10, a region associated with several genetic disorders, highlighting IFIT2′s potential implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IFIT2 Antibody (G-9) References:
- Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells. | Lai, KC., et al. 2013. Oncogene. 32: 3686-97. PMID: 22986528
- A role for Ifit2 in restricting West Nile virus infection in the brain. | Cho, H., et al. 2013. J Virol. 87: 8363-71. PMID: 23740986
- Interferon-induced protein Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus. | Fensterl, V., et al. 2014. J Virol. 88: 10303-11. PMID: 24991014
- Sendai virus pathogenesis in mice is prevented by Ifit2 and exacerbated by interferon. | Wetzel, JL., et al. 2014. J Virol. 88: 13593-601. PMID: 25231314
- Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity. | Davis, BM., et al. 2017. J Virol. 91: PMID: 28637751
- Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection. | Das Sarma, J., et al. 2020. PLoS Pathog. 16: e1009034. PMID: 33253295
- SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells. | Regmi, P., et al. 2020. Cancers (Basel). 12: PMID: 33256074
- IFIT2-depleted metastatic oral squamous cell carcinoma cells induce muscle atrophy and cancer cachexia in mice. | Lai, KC., et al. 2022. J Cachexia Sarcopenia Muscle. 13: 1314-1328. PMID: 35170238
- Ifit2 restricts murine coronavirus spread to the spinal cord white matter and its associated myelin pathology. | Sharma, M., et al. 2023. J Virol. 97: e0074923. PMID: 37504572
- The interferon-induced protein, IFIT2, requires RNA-binding activity and neuronal expression to protect mice from intranasal vesicular stomatitis virus infection. | Poddar, D., et al. 2024. mBio. 15: e0056824. PMID: 38888342
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFIT2 Antibody (G-9) | sc-398610 | 200 µg/ml | $316.00 | |||
IFIT2 Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-530872 | 200 µg Ab; 10 µg BP | $354.00 | |||
IFIT2 Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-524421 | 200 µg Ab, 40 µg BP | $354.00 | |||
IFIT2 Antibody (G-9) AC | sc-398610 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IFIT2 Antibody (G-9) HRP | sc-398610 HRP | 200 µg/ml | $316.00 | |||
IFIT2 Antibody (G-9) FITC | sc-398610 FITC | 200 µg/ml | $330.00 | |||
IFIT2 Antibody (G-9) PE | sc-398610 PE | 200 µg/ml | $343.00 | |||
IFIT2 Antibody (G-9) Alexa Fluor® 488 | sc-398610 AF488 | 200 µg/ml | $357.00 | |||
IFIT2 Antibody (G-9) Alexa Fluor® 546 | sc-398610 AF546 | 200 µg/ml | $357.00 | |||
IFIT2 Antibody (G-9) Alexa Fluor® 594 | sc-398610 AF594 | 200 µg/ml | $357.00 | |||
IFIT2 Antibody (G-9) Alexa Fluor® 647 | sc-398610 AF647 | 200 µg/ml | $357.00 | |||
IFIT2 Antibody (G-9) Alexa Fluor® 680 | sc-398610 AF680 | 200 µg/ml | $357.00 | |||
IFIT2 Antibody (G-9) Alexa Fluor® 790 | sc-398610 AF790 | 200 µg/ml | $357.00 |