IDS Antibody (E-4): sc-365149

IDS Antibody (E-4) is a mouse monoclonal IgG2b antibody that detects IDS (Iduronate 2-sulfatase) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IDS is a crucial enzyme localized in the lysosome, where IDS plays a vital role in the degradation of glycosaminoglycans, specifically dermatan sulfate and heparan sulfate. By catalyzing the hydrolysis of sulfate groups on these substrates, IDS ensures proper turnover of complex carbohydrates, which is essential for maintaining cellular homeostasis and preventing harmful metabolite accumulation. Deficiencies in IDS activity lead to substrate accumulation, resulting in mucopolysaccharidosis type 2 (MPS2), commonly known as Hunter syndrome, a disorder characterized by severe skeletal deformities, organ enlargement, progressive cardiopulmonary issues, and neurological decline. Anti-IDS antibody (E-4) is particularly valuable for researchers studying MPS2 pathophysiology and lysosomal function, as well as exploring potential therapeutic interventions. Additionally, IDS exists in two alternatively spliced isoforms, long and short, which may have distinct functional implications, making IDS (E-4) antibody an essential tool for further investigations into IDS biology.

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IDS Antibody (E-4) References:

1. Novel type of genetic rearrangement in the iduronate-2-sulfatase (IDS) gene involving deletion, duplications, and inversions.  |  Karsten, S., et al. 1999. Hum Mutat. 14: 471-6. PMID: 10571944
2. Gene therapy of Hunter syndrome: evaluation of the efficiency of muscle electro gene transfer for the production and release of recombinant iduronate-2-sulfatase (IDS).  |  Friso, A., et al. 2008. Biochim Biophys Acta. 1782: 574-80. PMID: 18675343
3. Molecular diagnosis of 65 families with mucopolysaccharidosis type II (Hunter syndrome) characterized by 16 novel mutations in the IDS gene: Genetic, pathological, and structural studies on iduronate-2-sulfatase.  |  Kosuga, M., et al. 2016. Mol Genet Metab. 118: 190-197. PMID: 27246110
4. Comparative studies of vertebrate iduronate 2-sulfatase (IDS) genes and proteins: evolution of A mammalian X-linked gene.  |  Holmes, RS. 2017. 3 Biotech. 7: 22. PMID: 28401457
5. Anaerobic sulfatase maturase AslB from Escherichia coli activates human recombinant iduronate-2-sulfate sulfatase (IDS) and N-acetylgalactosamine-6-sulfate sulfatase (GALNS).  |  Alméciga-Díaz, CJ., et al. 2017. Gene. 634: 53-61. PMID: 28882567
6. A Phase 2/3 Trial of Pabinafusp Alfa, IDS Fused with Anti-Human Transferrin Receptor Antibody, Targeting Neurodegeneration in MPS-II.  |  Okuyama, T., et al. 2021. Mol Ther. 29: 671-679. PMID: 33038326
7. Characterization of a HIR-Fab-IDS, Novel Iduronate 2-Sulfatase Fusion Protein for the Treatment of Neuropathic Mucopolysaccharidosis Type II (Hunter Syndrome).  |  Gusarova, VD., et al. 2023. BioDrugs. 37: 375-395. PMID: 37014547
8. A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes.  |  Badenetti, L., et al. 2023. Sci Rep. 13: 10289. PMID: 37357221
9. Production of active human iduronate-2-sulfatase (IDS) enzyme in Nicotiana benthamiana.  |  Sinha, MH., et al. 2024. Sci Rep. 14: 23066. PMID: 39367006
10. Mutations of the iduronate-2-sulfatase (IDS) gene in patients with Hunter syndrome (mucopolysaccharidosis II).  |  Schröder, W., et al. 1994. Hum Mutat. 4: 128-31. PMID: 7981716

The preferred IDS antibody is IDS Antibody (B-5): sc-365047.