IDS Inhibitors
IDS Inhibitors can be defined as a class of compounds that reduce the activity of the enzyme Iduronate 2-sulfatase (IDS). The chemicals in this class engage in a diverse set of interactions and mechanisms to influence IDS activity, often by modulating pathways and processes related to IDS function.
The IDS enzyme plays a crucial role in the degradation of glycosaminoglycans (GAGs) within the lysosome. Therefore, compounds that influence GAG metabolism, lysosomal function, or related cellular processes may serve as indirect inhibitors of IDS. For instance, Genistein, Chloroquine, Bafilomycin A1, Ammonium chloride, Monensin, and Methylamine could inhibit IDS activity by disrupting the lysosomal environment or influencing cellular metabolism. Additional inhibitors like Nocodazole, Colchicine, Cytochalasin D, and Dynasore can interfere with the transport of IDS to the lysosome, which is crucial for its activity. Progesterone and Estradiol, on the other hand, are known to affect various cellular processes and could inhibit IDS activity indirectly.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can impact numerous cellular processes, including lysosomal enzyme activity. It may indirectly downregulate IDS activity by influencing cellular metabolism. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar type H+ ATPase (V-ATPase) and can disrupt lysosomal acidification, potentially inhibiting IDS activity by disrupting the lysosomal environment. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Similar to Chloroquine, Ammonium chloride can increase lysosomal pH, potentially inhibiting IDS activity. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts lysosomal processes by altering ion balances, potentially reducing IDS activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule dynamics, which can impair the transport of IDS to the lysosome, potentially reducing its activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine is a microtubule inhibitor and could reduce the activity of IDS by disrupting its transport to the lysosome. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin filaments and can interfere with vesicle trafficking, potentially reducing the transport of IDS to the lysosome and its activity. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a dynamin inhibitor that can disrupt endocytosis, potentially affecting the transport of IDS to the lysosome and reducing its activity. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone is known to inhibit lysosomal enzymes, potentially reducing the activity of IDS. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol can influence various cellular processes and may indirectly affect IDS activity. | ||||||