IDO Antibody (H-11): sc-137012

IDO Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects IDO in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-IDO antibody (H-11) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Indoleamine 2,3-dioxygenase (IDO) plays a crucial role in immune regulation by catalyzing the degradation of the essential amino acid L-tryptophan into N-formylkynurenine, a process that is particularly important in the context of immune tolerance and response. IDO is induced by interferon-gamma and modulates immunological responses, thereby protecting allogeneic concepti from maternal immune rejection. IDO activity can inhibit T cell proliferation, as demonstrated in studies where IDO-transfected cells co-cultured with T cells resulted in reduced T cell activity. Additionally, IDO presence in dendritic cells suppresses T cell responses, highlighting significance in maintaining immune homeostasis. The gene encoding human IDO is located on chromosome 8p12-p11, and understanding IDO function and interactions is vital for developing therapeutic strategies aimed at manipulating immune responses, particularly in the context of cancer and transplantation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IDO Antibody (H-11) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-IDO Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IDO Antibody (H-11) Specifications

Alternate Product Name: IDO

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-80

Epitope Target: IDO

Epitope Species: mouse

Product Reactivity/Detection: IDO

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for IDO Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred IDO antibody is IDO Antibody (mIDO-48): sc-53978.