ICAM-3 Antibody (By44): sc-53337

ICAM-3 Antibody (By44) is a mouse monoclonal IgG1 antibody that detects ICAM-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in immune responses by facilitating cell-cell interactions, particularly during T cell activation and migration. ICAM-3 is primarily located on the surface of leukocytes, where anti-ICAM-3 antibody (By44) acts as a counter-receptor for the leukocyte integrin αLβ2, thereby promoting the adhesion and activation of T cells and polymorphonuclear leukocytes. ICAM-3′s location in the immune system is underscored by its ability to mediate interactions essential for effective immune surveillance and response. Additionally, RANTES, a chemokine that attracts T lymphocytes to sites of inflammation, induces ICAM-3 expression, further highlighting its importance in regulating immune cell trafficking. ICAM-3 also interacts with Moesin through its cytoplasmic domain, linking ICAM-3 to the cytoskeleton and influencing cellular morphology during immune responses. With critical functions in immune regulation and cell adhesion, ICAM-3 is a vital target for research in immunology and related fields. ICAM-3 monoclonal antibody (By44) is an essential tool for studying these processes in human samples.

The preferred ICAM-3 antibody is ICAM-3 Antibody (CG106): sc-53338.