ICAM-3 Antibody (3.1): sc-9971

ICAM-3 Antibody (3.1) is a mouse monoclonal IgG1 antibody that detects ICAM-3 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in immune responses by facilitating cell adhesion and communication. ICAM-3 is primarily located on the surface of leukocytes, where ICAM-3 acts as a counter-receptor for the leukocyte integrin αL/β2, thereby promoting T cell activation and enhancing the immune response. The interaction of ICAM-3 with integrins is vital for the migration of immune cells to sites of inflammation, making ICAM-3 an important player in both innate and adaptive immunity. Additionally, ICAM-3′s expression is induced by RANTES, a chemokine that attracts T lymphocytes, further underscoring ICAM-3′s significance in immune cell trafficking and activation. The binding of ICAM-3 to Moesin through its cytoplasmic domain also suggests a role in cytoskeletal organization during cell movement, highlighting ICAM-3′s importance in maintaining cellular architecture during immune responses.

The preferred ICAM-3 antibody is ICAM-3 Antibody (CG106): sc-53338.