ICAM-3 Antibody (2Q700): sc-71306

ICAM-3 Antibody (2Q700) is a mouse monoclonal IgG2b antibody that detects ICAM-3 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in immune responses by facilitating cell-cell interactions, particularly during T cell activation and migration. ICAM-3 is primarily located on the surface of leukocytes, where ICAM-3 acts as a counter-receptor for the leukocyte integrin αL/β2, thereby influencing the adhesion and movement of immune cells to sites of inflammation. The interaction of ICAM-3 with integrins is vital for the proper functioning of the immune system, as ICAM-3 helps regulate the morphological changes necessary for leukocyte locomotion. Additionally, ICAM-3′s expression is induced by RANTES, a chemokine that activates T lymphocytes, further underscoring ICAM-3′s importance in immune responses. ICAM-3′s ability to bind to Moesin through its cytoplasmic domain also highlights ICAM-3′s role in linking the cytoskeleton to the plasma membrane, which is essential for maintaining cell shape and motility. With its multifaceted functions in immune regulation and cell adhesion, ICAM-3 is a significant target for research in immunology and related fields.

The preferred ICAM-3 antibody is ICAM-3 Antibody (CG106): sc-53338.