ICAM-3 Antibody (101-1D2): sc-21776

ICAM-3 Antibody (101-1D2) is a mouse monoclonal IgG2a antibody that detects ICAM-3 in human samples through flow cytometry (FCM). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in immune responses by facilitating cell-cell interactions, particularly during T cell activation and migration. ICAM-3 is primarily located on the surface of leukocytes, where ICAM-3 acts as a counter-receptor for the leukocyte integrin αL/β2, thereby promoting the adhesion and activation of T cells and polymorphonuclear leukocytes. ICAM-3′s location is crucial for regulating morphological changes during cell locomotion, which is essential for effective immune responses. Additionally, RANTES, a chemokine that attracts T lymphocytes to sites of inflammation, induces ICAM-3 expression, further highlighting ICAM-3′s importance in immune system dynamics. ICAM-3 also interacts with Moesin through its cytoplasmic domain, linking ICAM-3 to the cytoskeleton and influencing cellular signaling pathways. This multifaceted role in immune regulation makes anti-ICAM-3 antibody (101-1D2) an invaluable tool for researchers studying immune responses and cell adhesion mechanisms.

The preferred ICAM-3 antibody is ICAM-3 Antibody (CG106): sc-53338.