ICAM-2 Antibody (CBR-IC2/2): sc-23935

ICAM-2 Antibody (CBR-IC2/2) is a mouse monoclonal IgG2a antibody that detects ICAM-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). ICAM-2, also known as CD102, is a crucial member of the intercellular adhesion molecule family, primarily expressed on endothelial cells and leukocytes, where ICAM-2 (CBR-IC2/2) antibody plays a significant role in mediating leukocyte adhesion and migration during immune responses. ICAM-2 serves as a ligand for lymphocyte function-associated antigen-1 (LFA-1), facilitating the interaction between leukocytes and endothelial cells, which is essential for the immune system′s ability to respond to inflammation and infection. Proper functioning of ICAM-2 is vital for maintaining immune homeostasis, and dysregulation of ICAM-2 expression can lead to various inflammatory diseases and conditions. Anti-ICAM-2 antibody (CBR-IC2/2) enables researchers to gain insights into the mechanisms of immune cell trafficking and the role of ICAM-2 in various pathological states, making this research tool invaluable for studies in immunology and cell biology.

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ICAM-2 Antibody (CBR-IC2/2) References:

1. Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3.  |  Bleijs, DA., et al. 1999. Eur J Immunol. 29: 2248-58. PMID: 10427988
2. Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN.  |  Weber, KS., et al. 2004. Inflammation. 28: 177-88. PMID: 15673159
3. ICAM-1, ICAM-2 and ICAM-3 in the sera of patients with idiopathic pulmonary fibrosis.  |  Tsoutsou, PG., et al. 2004. Inflammation. 28: 359-64. PMID: 16245079
4. Inhibition of ICAM2 induces radiosensitization in oral squamous cell carcinoma cells.  |  Ishigami, T., et al. 2008. Br J Cancer. 98: 1357-65. PMID: 18349842
5. Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.  |  Porter, JC. and Hall, A. 2009. FASEB J. 23: 492-502. PMID: 18842965
6. ICAM-2 regulates vascular permeability and N-cadherin localization through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling.  |  Amsellem, V., et al. 2014. Cell Commun Signal. 12: 12. PMID: 24593809
7. ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin.  |  Feduska, JM., et al. 2015. Oncogene. 34: 1553-62. PMID: 24704826
8. Endothelium adhesion molecules ICAM-1, ICAM-2, VCAM-1 and VLA-4 expression in leprosy.  |  de Sousa, J., et al. 2017. Microb Pathog. 104: 116-124. PMID: 28088473
9. ICAM2 initiates trans-blood-CSF barrier migration and stemness properties in leptomeningeal metastasis of triple-negative breast cancer.  |  Pan, JK., et al. 2023. Oncogene. 42: 2919-2931. PMID: 37620448
10. Role of ICAM-1 and ICAM-2 and alternate CD11/CD18 ligands in neutrophil transendothelial migration.  |  Issekutz, AC., et al. 1999. J Leukoc Biol. 65: 117-26. PMID: 9886254

The preferred ICAM-2 antibody is ICAM-2 Antibody (F-5): sc-9987.