ICAM-2 Antibody (F-5): sc-9987

ICAM-2 Antibody (F-5) is a mouse monoclonal IgA kappa light chain antibody that detects ICAM-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). ICAM-2 Antibody (F-5) is available in non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). ICAM-2, a member of the immunoglobulin superfamily, plays a crucial role in mediating leukocyte adhesion and migration, essential for immune response and inflammation. ICAM-2 is primarily located on endothelial cells and leukocytes, facilitating interaction between lymphocytes and endothelial cells during immune surveillance and inflammatory responses. Proper functioning of ICAM-2 maintains vascular integrity and regulates immune cell trafficking, making ICAM-2 significant in normal physiological processes and pathological conditions like autoimmune diseases and chronic inflammation. ICAM-2 interacts with lymphocyte function-associated antigen-1 (LFA-1), enhancing leukocyte adhesion to endothelium, critical for immune cell recruitment to injury or infection sites. anti-ICAM-2 antibody (F-5) versatility in various applications helps researchers explore ICAM-2′s role in diverse biological contexts, contributing to deeper understanding of immune mechanisms and potential therapeutic targets.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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ICAM-2 Antibody (F-5) References:

1. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18.  |  Tian, L., et al. 2000. Eur J Immunol. 30: 810-8. PMID: 10741396
2. Ligation of intercellular adhesion molecule 3 inhibits GM-CSF production by human eosinophils.  |  Kessel, JM., et al. 2003. J Allergy Clin Immunol. 111: 1024-31. PMID: 12743567
3. Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to alpha V integrins.  |  Mankelow, TJ., et al. 2004. Blood. 103: 1503-8. PMID: 14551135
4. ICAM-2 expression mediates a membrane-actin link, confers a nonmetastatic phenotype and reflects favorable tumor stage or histology in neuroblastoma.  |  Yoon, KJ., et al. 2008. PLoS One. 3: e3629. PMID: 18978946
5. Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells: implications in the design of gammadelta-T-cell-based immunotherapies for pancreatic cancer.  |  Liu, Z., et al. 2009. J Gastroenterol Hepatol. 24: 900-11. PMID: 19175829
6. N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells.  |  Feduska, JM., et al. 2013. BMC Cancer. 13: 261. PMID: 23714211
7. The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues.  |  Lyck, R. and Enzmann, G. 2015. Curr Opin Hematol. 22: 53-9. PMID: 25427141
8. ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo.  |  Chong, DLW., et al. 2021. Front Immunol. 12: 691957. PMID: 34484188
9. Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling.  |  Jørgensen, OS. 1995. Neurochem Res. 20: 533-47. PMID: 7643959
10. Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor alpha 4 beta 7. Common themes among integrin-Ig family interactions.  |  Briskin, MJ., et al. 1996. J Immunol. 156: 719-26. PMID: 8543825
11. Developmental control of N-CAM expression by Hox and Pax gene products.  |  Edelman, GM. and Jones, FS. 1995. Philos Trans R Soc Lond B Biol Sci. 349: 305-12. PMID: 8577842
12. Binding of the cytoplasmic domain of intercellular adhesion molecule-2 (ICAM-2) to alpha-actinin.  |  Heiska, L., et al. 1996. J Biol Chem. 271: 26214-9. PMID: 8824270

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ICAM-2 Antibody (F-5) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-ICAM-2 Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ICAM-2 Antibody (F-5) Specifications

Alternate Product Name: ICAM-2

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 65-223

Epitope Target: ICAM-2

Epitope Species: human

Product Reactivity/Detection: ICAM-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for ICAM-2 Antibody (F-5): FITC: Fluoroscein, PE: Phycoerythrin