IAP Antibody (AP-7/6/7): sc-53334
- IAP Antibody (AP-7/6/7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against calf intestinal alkaline phosphatase
- recommended for detection of IAP of bovine origin by IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IAP Antibody (AP-7/6/7). These reagents are now offered in bundles with IAP Antibody (AP-7/6/7) (see ordering information below).
IAP Antibody (AP-7/6/7) is a mouse monoclonal IgG1 antibody that detects intestinal alkaline phosphatase (IAP) in bovine samples through immunofluorescence (IF) applications. Anti-IAP antibody (AP-7/6/7) recognizes a brush-border enzyme that increases significantly during small intestinal epithelial cell differentiation. IAP plays an essential role in limiting fat absorption and participates in trans-cellular transport and chylomicron formation, which are critical for lipid metabolism. IAP functions optimally at high pH levels, removing phosphate groups from proteins and the 5′ ends of DNA and RNA, thereby influencing various biochemical pathways. IAP expression is notably present in tissues such as the liver, bile ducts, placenta, and bone, with expression levels serving as potential biomarkers for various conditions, including bone and liver diseases. Serum IAP levels vary among different ABO blood groups, with individuals of blood group O or B showing higher prevalence, potentially affecting fatty acid metabolism. IAP monoclonal antibody (AP-7/6/7) serves as a valuable tool for researchers studying this enzyme′s roles in bovine physiology and pathology.
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IAP Antibody (AP-7/6/7) References:
- IAP guidelines in acute pancreatitis. | Sarr, MG. 2003. Dig Surg. 20: 1-3. PMID: 12846213
- Targeting IAP proteins for therapeutic intervention in cancer. | Fulda, S. and Vucic, D. 2012. Nat Rev Drug Discov. 11: 109-24. PMID: 22293567
- IAP family of cell death and signaling regulators. | Silke, J. and Vucic, D. 2014. Methods Enzymol. 545: 35-65. PMID: 25065885
- Smac mimetics as IAP antagonists. | Fulda, S. 2015. Semin Cell Dev Biol. 39: 132-8. PMID: 25550219
- Targeting IAP proteins in combination with radiotherapy. | Fulda, S. 2015. Radiat Oncol. 10: 105. PMID: 25927408
- Smac Mimetics to Therapeutically Target IAP Proteins in Cancer. | Fulda, S. 2017. Int Rev Cell Mol Biol. 330: 157-169. PMID: 28215531
- SNIPERs-Hijacking IAP activity to induce protein degradation. | Naito, M., et al. 2019. Drug Discov Today Technol. 31: 35-42. PMID: 31200857
- IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling. | Dumétier, B., et al. 2020. Cells. 9: PMID: 32365919
- The Multiple Roles of the IAP Super-family in cancer. | Kumar, S., et al. 2020. Pharmacol Ther. 214: 107610. PMID: 32585232
- Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents. | Wang, C., et al. 2022. J Enzyme Inhib Med Chem. 37: 1437-1453. PMID: 35589670
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IAP Antibody (AP-7/6/7) | sc-53334 | 200 µg/ml | $322.00 | |||
IAP Antibody (AP-7/6/7): m-IgG Fc BP-HRP Bundle | sc-536937 | 200 µg Ab; 10 µg BP | $361.00 | |||
IAP Antibody (AP-7/6/7): m-IgGκ BP-HRP Bundle | sc-534113 | 200 µg Ab; 40 µg BP | $361.00 | |||
IAP Antibody (AP-7/6/7): m-IgG1 BP-HRP Bundle | sc-544910 | 200 µg Ab; 20 µg BP | $361.00 |