HuR/ELAV1 Antibody (6A97): sc-71290

HuR Antibody (6A97) is a mouse monoclonal IgG1 kappa light chain antibody that detects HuR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HuR antibody (6A97) is available in a non-conjugated form, specifically targeting HuR, which is a member of the Elav-like family of RNA-binding proteins. These proteins play a crucial role in post-transcriptional regulation of gene expression, particularly in mRNA stability and translation. HuR, also known as Human antigen R or ELAVL1, is ubiquitously expressed and is notably overexpressed in various tumors, highlighting its importance in cancer biology. HuR contains three RNA recognition motifs (RRM) that enable binding specifically to AU-rich elements (ARE) located in the 3′-untranslated regions of mRNA transcripts. This interaction is vital as ARE sites are responsible for targeting mRNA for rapid degradation, thus regulating the expression levels of genes involved in critical cellular processes such as growth and differentiation. By binding to these ARE sites, HuR inhibits mRNA degradation, leading to increased stability of the transcripts and ultimately influencing cellular responses. HuR shuttles between the nucleus and cytoplasm, a process regulated by a nuclear export signal that modulates accessibility to ARE sites, thereby playing a significant role in the post-transcriptional control of gene expression.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HuR/ELAV1 Antibody (6A97) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-HuR/ELAV1 Antibody (6A97) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HuR/ELAV1 Antibody (6A97) Specifications

Alternate Product Name: ELAVL4

Product Clone Name: 6A97

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HuR

Epitope Species: human

Product Reactivity/Detection: HuR, HuB, HuC and HuD

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: Xenopus

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for HuR/ELAV1 Antibody (6A97): N/A

The preferred HuR/ELAV1 antibody is HuR/ELAV1 Antibody (3A2): sc-5261.