HtrA2 Antibody (C-10): sc-271528

HtrA2 Antibody (C-10) is a mouse monoclonal IgG1 antibody that detects HtrA2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HtrA2, also known as Omi, is a crucial member of the HtrA serine protease family, playing a significant role in cellular homeostasis by degrading misfolded proteins, particularly during cellular stress. HtrA2 is predominantly localized in the mitochondria, where HtrA2 contributes to the regulation of apoptosis and cellular stress responses. The mitochondrial localization of HtrA2 is vital, as this positioning allows HtrA2 to act as a guardian of mitochondrial integrity, preventing the accumulation of damaged proteins that could lead to cell death. Additionally, HtrA2 undergoes post-translational modifications, including phosphorylation and cleavage, which are essential for activation and functional regulation. These modifications can influence proteolytic activity and interactions with other proteins, such as Mxi2, which is known to be a partner of HtrA2 under certain conditions. anti-HtrA2 antibody (C-10) is an invaluable tool for researchers studying the mechanisms of protein quality control and the role of HtrA2 in various diseases, including neurodegenerative disorders and cancer.

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HtrA2 Antibody (C-10) References:

1. Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target.  |  Bhuiyan, MS. and Fukunaga, K. 2009. Curr Drug Targets. 10: 372-83. PMID: 19355862
2. HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.  |  Goo, HG., et al. 2013. Biochim Biophys Acta. 1833: 1866-75. PMID: 23542127
3. HTRA2 variations in Taiwanese Parkinson's disease.  |  Chen, CM., et al. 2014. J Neural Transm (Vienna). 121: 491-8. PMID: 24337630
4. HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis.  |  Goo, HG., et al. 2014. Exp Cell Res. 328: 456-65. PMID: 25094062
5. HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.  |  Lee, SH., et al. 2016. Sci Rep. 6: 39393. PMID: 28008946
6. p53 mediated transcription of Omi/HtrA2 in aging myocardium.  |  Wu, L., et al. 2019. Biochem Biophys Res Commun. 519: 734-739. PMID: 31543347
7. HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis.  |  Xu, Z., et al. 2021. Mol Immunol. 129: 78-85. PMID: 33229071
8. HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia.  |  Nam, MK., et al. 2023. Biochem Biophys Res Commun. 638: 84-93. PMID: 36442236
9. Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway.  |  Li, Y., et al. 2022. Free Radic Res. 56: 651-665. PMID: 36592372
10. APP deficiency and HTRA2 modulates PrPc proteostasis in human cancer cells.  |  Biard, DSF., et al. 2022. BBA Adv. 2: 100035. PMID: 37082595

The preferred HtrA2 antibody is HtrA2 Antibody (E-3): sc-365594.