HSV-1 UL42 Antibody (2H4): sc-53333

HSV-1 UL42 Antibody (2H4) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSV-1 UL42 protein of HSV-1 origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-HSV-1 UL42 antibody (2H4) plays a crucial role in understanding the herpes simplex virus, which is known for causing contagious diseases such as cold sores and fever blisters. HSV-1 UL42 (2H4) antibody recognizes UL42 protein, which serves as the processivity subunit of the HSV-1 DNA polymerase, a vital component in viral replication. UL42 protein enhances the stability of the DNA polymerase complex during replication by binding to DNA as a monomer, which is essential for maintaining viral genome integrity. This interaction significantly reduces dissociation from primer-template DNA, facilitating efficient DNA synthesis. UL42 protein enhances UL9 loading onto DNA, promoting the assembly of a functional complex capable of unwinding duplex DNA, which is critical for initiating viral replication. Research on UL42 protein in the viral life cycle provides insights into HSV-1 pathogenesis and potential therapeutic interventions targeting viral replication mechanisms.

The preferred HSV-1 UL42 antibody is HSV-1 UL42 Antibody (13C9): sc-53331.