HSV-1 gD Antibody (DL6): sc-21719
- HSV-1 gD Antibody (DL6) is a mouse monoclonal IgG2a κ HSV-1 gD antibody, cited in 75 publications, provided at 200 µg/ml
- epitope mapping to amino acids 272-279 of HSV gD
- HSV-1 gD Antibody (DL6) is recommended for detection of HSV-1 glycoprotein D of HSV-1 origin by WB, IP and FCM
- Anti-HSV-1 gD Antibody (DL6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HSV-1 gD Antibody (DL6) for WB applications. These reagents are now offered in bundles with HSV-1 gD Antibody (DL6) (see ordering information below).
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HSV-1 gD Antibody (DL6) is a mouse monoclonal IgG2a kappa light chain antibody that detects HSV-1 gD protein of HSV-1 origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). HSV-1 gD (DL6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The glycoprotein D (gD) plays a pivotal role in the entry of herpes simplex virus into host cells, as gD is essential for the fusion of the viral envelope with the host cell membrane. This process is critical for viral infection and propagation, as glycoprotein D interacts with specific receptors on the surface of target cells, facilitating virus entry. Notably, glycoprotein D′s ability to bind to cellular receptors is crucial for virus infectivity, as gD initiates a series of conformational changes that lead to membrane fusion. The interaction of glycoprotein D with the gH/gL heterodimer further enhances this process, underscoring gD′s importance in the viral life cycle. Understanding glycoprotein D function is vital for developing therapeutic strategies against HSV infections, as targeting gD could potentially inhibit viral entry and spread.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSV-1 gD Antibody (DL6) References:
- Monoclonal antibodies suitable for type-specific identification of herpes simplex viruses by a rapid culture assay. | Bystrická, M., et al. 1999. Acta Virol. 43: 399-402. PMID: 10825932
- Characterization of cell-cell fusion mediated by herpes simplex virus 2 glycoproteins gB, gD, gH and gL in transfected cells. | Muggeridge, MI. 2000. J Gen Virol. 81: 2017-2027. PMID: 10900041
- Assembly and organization of glycoproteins B, C, D, and H in herpes simplex virus type 1 particles lacking individual glycoproteins: No evidence for the formation of a complex of these molecules. | Rodger, G., et al. 2001. J Virol. 75: 710-6. PMID: 11134284
- Plasma membrane requirements for cell fusion induced by herpes simplex virus type 1 glycoproteins gB, gD, gH and gL. | Browne, H., et al. 2001. J Gen Virol. 82: 1419-1422. PMID: 11369886
- Type-common and type-specific monoclonal antibodies to herpes simplex virus types 1 and 2. | Bystrická, M., et al. 1991. Acta Virol. 35: 152-64. PMID: 1681713
- Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion. | Cai, WH., et al. 1988. J Virol. 62: 2596-604. PMID: 2839688
- Seroepidemiology and control of genital herpes: the value of type specific antibodies to herpes simplex virus. | Slomka, MJ. 1996. Commun Dis Rep CDR Rev. 6: R41-5. PMID: 8820192
- Monoclonal antibodies to the distinct antigenic sites on glycoproteins C and B and their protective abilities in herpes simplex virus infection. | Bystrická, M., et al. 1997. Acta Virol. 41: 5-12. PMID: 9199708
- Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system. | Turner, A., et al. 1998. J Virol. 72: 873-5. PMID: 9420303
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-1 gD Antibody (DL6) | sc-21719 | 200 µg/ml | $316.00 | |||
HSV-1 gD Antibody (DL6): m-IgG Fc BP-HRP Bundle | sc-528362 | 200 µg Ab; 10 µg BP | $354.00 | |||
HSV-1 gD Antibody (DL6): m-IgGκ BP-HRP Bundle | sc-520723 | 200 µg Ab, 40 µg BP | $354.00 | |||
HSV-1 gD Antibody (DL6): m-IgG2a BP-HRP Bundle | sc-547077 | 200 µg Ab; 10 µg BP | $354.00 | |||
HSV-1 gD Antibody (DL6) AC | sc-21719 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HSV-1 gD Antibody (DL6) HRP | sc-21719 HRP | 200 µg/ml | $316.00 | |||
HSV-1 gD Antibody (DL6) FITC | sc-21719 FITC | 200 µg/ml | $330.00 | |||
HSV-1 gD Antibody (DL6) PE | sc-21719 PE | 200 µg/ml | $343.00 | |||
HSV-1 gD Antibody (DL6) Alexa Fluor® 488 | sc-21719 AF488 | 200 µg/ml | $357.00 | |||
HSV-1 gD Antibody (DL6) Alexa Fluor® 546 | sc-21719 AF546 | 200 µg/ml | $357.00 | |||
HSV-1 gD Antibody (DL6) Alexa Fluor® 594 | sc-21719 AF594 | 200 µg/ml | $357.00 | |||
HSV-1 gD Antibody (DL6) Alexa Fluor® 647 | sc-21719 AF647 | 200 µg/ml | $357.00 | |||
HSV-1 gD Antibody (DL6) Alexa Fluor® 680 | sc-21719 AF680 | 200 µg/ml | $357.00 | |||
HSV-1 gD Antibody (DL6) Alexa Fluor® 790 | sc-21719 AF790 | 200 µg/ml | $357.00 |