HSP70 Antibody (N27F3-4): sc-66049

HSP 70 Antibody (N27F3-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSP 70 across a broad range of mammalian species, as well as Drosophila melanogaster, zebrafish, Caenorhabditis elegans, and plant origins, by applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). HSP 70 (N27F3-4) antibody is available in a non-conjugated form, allowing for versatile experimental use. HSP 70 plays a crucial role as a molecular chaperone, facilitating proper folding of nascent polypeptide chains and preventing aggregation of misfolded proteins, which is vital for maintaining cellular homeostasis and function. HSP 70 expression significantly increases under stress conditions, such as heat shock, protecting cells from damage. HSP 70 is predominantly located in the cytosol and nucleus of mammalian cells, assisting in polypeptide translocation across cellular membranes and into the nucleus, ensuring proteins reach correct destinations and maintain functional conformations. HSP 70′s response to cellular stressors highlights its significance in various physiological and pathological processes, including development, aging, and disease states such as cancer, where HSP 70 can influence cell survival and apoptosis.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSP70 Antibody (N27F3-4) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-HSP70 Antibody (N27F3-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSP70 Antibody (N27F3-4) Specifications

Alternate Product Name: heat shock protein A (Hsp70)

Product Clone Name: N27F3-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 403-640

Epitope Target: HSP 70/HSC 70

Epitope Species: human

Product Reactivity/Detection: HSP 70

Species Reactivity/Detection: broad mammalian species

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: Drosophila melanogaster, zebrafish, Caenorhabditis elegans, plants

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for HSP70 Antibody (N27F3-4): N/A

The preferred HSC70/HSP70 antibody is HSC70/HSP70 Antibody (W27): sc-24.