HSP70 Antibody (4G4): sc-59569

HSP 70 Antibody (4G4) is a mouse monoclonal IgG2b antibody that detects HSP 70 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HSP 70 is a crucial member of the heat shock protein family, which plays a vital role in cellular stress responses, particularly in protecting cells from damage caused by heat and other stressors. HSP 70 functions primarily as a molecular chaperone, facilitating the proper folding of nascent polypeptide chains and preventing the aggregation of misfolded proteins, which is essential for maintaining cellular homeostasis. HSP 70 is predominantly located in the cytosol and nucleus of mammalian cells, where HSP 70 assists in the translocation of proteins across cellular membranes and into organelles, thereby ensuring that proteins reach their correct destinations and maintain their functional conformations. HSP 70′s ability to respond to stress by increasing expression levels is critical for cell survival, particularly under conditions that induce protein misfolding. Additionally, HSP 70 interacts with various co-chaperones and client proteins, forming complexes that are essential for protein quality control and cellular signaling pathways. Anti-HSP 70 antibody (4G4) is an invaluable tool for researchers studying the dynamics of protein folding and the cellular response to stress, providing insights into the mechanisms underlying various diseases associated with protein misfolding and aggregation.

The preferred HSC70/HSP70 antibody is HSC70/HSP70 Antibody (W27): sc-24.