HSF2BP Antibody (5): sc-130322
- HSF2BP Antibody (5) is a mouse monoclonal IgG1 κ HSF2BP antibody provided at 200 µg/ml
- raised against recombinant HSF2BP of human origin
- HSF2BP Antibody (5) is recommended for detection of HSF2BP of human origin by WB and ELISA
- Anti-HSF2BP Antibody (5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSF2BP Antibody (5). This work is in progress.
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HSF2BP Antibody (5) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSF2BP protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-HSF2BP antibody (5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSF2BP, or heat shock factor 2-binding protein, consists of 334 amino acids and is encoded by the human gene HSF2BP. Notably, HSF2BP features an N-terminal hydrophilic region that adopts an α-helical structure, containing two leucine zipper motifs, while the C-terminal region is predominantly hydrophobic and forms β sheets. This structural arrangement facilitates interaction between HSF2BP and heat shock factor 2 (HSF2), a protein playing a significant role in cellular differentiation and development rather than responding to environmental stressors like heat. HSF2BP is specifically expressed in the testis, where HSF2BP associates with HSF2, indicating a potential role in modulating HSF2 activation during spermatogenesis. This interaction occurs through the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP, underscoring HSF2BP′s importance in regulating heat shock response pathways in reproductive tissues.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSF2BP Antibody (5) References:
- Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. | He, H., et al. 2003. J Biol Chem. 278: 35465-75. PMID: 12813038
- Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. | Jakobs, A., et al. 2007. Nucleic Acids Res. 35: e109. PMID: 17709345
- Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities. | Goodson, ML., et al. 1995. Mol Cell Biol. 15: 5288-93. PMID: 7565677
- Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. | Sarge, KD., et al. 1994. Biol Reprod. 50: 1334-43. PMID: 8080921
- Novel testis-specific protein that interacts with heat shock factor 2. | Yoshima, T., et al. 1998. Gene. 214: 139-46. PMID: 9651507
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSF2BP Antibody (5) | sc-130322 | 200 µg/ml | $322.00 | |||
HSF2BP Antibody (5) AC | sc-130322 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HSF2BP Antibody (5) HRP | sc-130322 HRP | 200 µg/ml | $322.00 | |||
HSF2BP Antibody (5) FITC | sc-130322 FITC | 200 µg/ml | $336.00 | |||
HSF2BP Antibody (5) PE | sc-130322 PE | 200 µg/ml | $349.00 | |||
HSF2BP Antibody (5) Alexa Fluor® 488 | sc-130322 AF488 | 200 µg/ml | $364.00 | |||
HSF2BP Antibody (5) Alexa Fluor® 546 | sc-130322 AF546 | 200 µg/ml | $364.00 | |||
HSF2BP Antibody (5) Alexa Fluor® 594 | sc-130322 AF594 | 200 µg/ml | $364.00 | |||
HSF2BP Antibody (5) Alexa Fluor® 647 | sc-130322 AF647 | 200 µg/ml | $364.00 | |||
HSF2BP Antibody (5) Alexa Fluor® 680 | sc-130322 AF680 | 200 µg/ml | $364.00 | |||
HSF2BP Antibody (5) Alexa Fluor® 790 | sc-130322 AF790 | 200 µg/ml | $364.00 |