HPS-4 Antibody (A-6): sc-398070
- HPS-4 Antibody (A-6) is a mouse monoclonal IgG2b κ HPS-4 antibody provided at 200 µg/ml
- raised against amino acids 526-671 mapping at the C-terminus of HPS-4 of mouse origin
- HPS-4 Antibody (A-6) is recommended for detection of HPS-4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-HPS-4 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HPS-4 Antibody (A-6) for WB applications. These reagents are now offered in bundles with HPS-4 Antibody (A-6) (see ordering information below).
HPS-4 Antibody (A-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects HPS-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HPS-4 (A-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HPS-4 protein, also known as light-ear protein homolog, plays a crucial role in the biogenesis of lysosome-related organelles, which are essential for various cellular functions, including processing and storage of cellular waste and transport of proteins. Defects in HPS4 gene, which encodes HPS-4 protein, can lead to Hermansky-Pudlak syndrome type 4, a rare genetic disorder characterized by oculocutaneous albinism, lysosomal storage defects, and prolonged bleeding due to platelet storage pool deficiency. HPS-4 interaction with other proteins within the biogenesis of lysosome-related organelle complexes is vital for maintaining cellular homeostasis and function, highlighting HPS-4 importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPS-4 Antibody (A-6) References:
- Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. | Hirosawa, M., et al. 2001. DNA Res. 8: 1-9. PMID: 11258795
- Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene. | Suzuki, T., et al. 2002. Nat Genet. 30: 321-4. PMID: 11836498
- Hermansky-Pudlak syndrome: vesicle formation from yeast to man. | Huizing, M., et al. 2002. Pigment Cell Res. 15: 405-19. PMID: 12453182
- Hermansky-Pudlak syndrome type 4 (HPS-4): clinical and molecular characteristics. | Anderson, PD., et al. 2003. Hum Genet. 113: 10-7. PMID: 12664304
- Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4. | Nazarian, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 8770-5. PMID: 12847290
- Hermansky-Pudlak syndrome type 4 in a patient from Sri Lanka with pulmonary fibrosis. | Bachli, EB., et al. 2004. Am J Med Genet A. 127A: 201-7. PMID: 15108212
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPS-4 Antibody (A-6) | sc-398070 | 200 µg/ml | $322.00 | |||
HPS-4 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-530688 | 200 µg Ab; 10 µg BP | $361.00 | |||
HPS-4 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-524210 | 200 µg Ab, 40 µg BP | $361.00 | |||
HPS-4 Antibody (A-6): m-IgG2b BP-HRP Bundle | sc-550212 | 200 µg Ab; 10 µg BP | $361.00 | |||
HPS-4 Antibody (A-6) AC | sc-398070 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HPS-4 Antibody (A-6) HRP | sc-398070 HRP | 200 µg/ml | $322.00 | |||
HPS-4 Antibody (A-6) FITC | sc-398070 FITC | 200 µg/ml | $336.00 | |||
HPS-4 Antibody (A-6) PE | sc-398070 PE | 200 µg/ml | $349.00 | |||
HPS-4 Antibody (A-6) Alexa Fluor® 488 | sc-398070 AF488 | 200 µg/ml | $364.00 | |||
HPS-4 Antibody (A-6) Alexa Fluor® 546 | sc-398070 AF546 | 200 µg/ml | $364.00 | |||
HPS-4 Antibody (A-6) Alexa Fluor® 594 | sc-398070 AF594 | 200 µg/ml | $364.00 | |||
HPS-4 Antibody (A-6) Alexa Fluor® 647 | sc-398070 AF647 | 200 µg/ml | $364.00 | |||
HPS-4 Antibody (A-6) Alexa Fluor® 680 | sc-398070 AF680 | 200 µg/ml | $364.00 | |||
HPS-4 Antibody (A-6) Alexa Fluor® 790 | sc-398070 AF790 | 200 µg/ml | $364.00 |