HPRG Antibody (G-10): sc-398239
- HPRG Antibody (G-10) is a mouse monoclonal IgG2b κ HPRG antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 125-149 near the N-terminus of HPRG of human origin
- HPRG Antibody (G-10) is recommended for detection of mature HRG and HPRG precursor of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- Anti-HPRG Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HPRG Antibody (G-10) for WB applications. These reagents are now offered in bundles with HPRG Antibody (G-10) (see ordering information below).
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HPRG Antibody (G-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects HPRG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HPRG (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The histidine-proline-rich glycoprotein (HPRG) plays a significant role in blood coagulation regulation, particularly in the contact activation phase of the intrinsic pathway. HPRG is primarily expressed in the liver and secreted into plasma, where HPRG interacts with various proteins, including thrombospondin, heparin, and plasminogen, which are crucial for maintaining hemostasis and modulating inflammatory responses. HPRG′s unique structure, characterized by high proline and histidine content along with numerous internal repeat sequences, allows HPRG to bind to dyes, heme, and divalent metal ions, further emphasizing HPRG′s importance in physiological processes. HPRG′s ability to inhibit rosette formation also suggests a potential role in cell signaling and immune response modulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPRG Antibody (G-10) References:
- Interactions of rab5 with cytosolic proteins. | Kurzchalia, TV., et al. 1992. J Biol Chem. 267: 18419-23. PMID: 1526983
- Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. | Doñate, F., et al. 2004. Cancer Res. 64: 5812-7. PMID: 15313924
- Silicone band technique for laparoscopic tubal sterilization in the gravid and nongravid patient. | Beck, P. and Gal, D. 1979. Obstet Gynecol. 53: 653-6. PMID: 155789
- Heat stroke-induced multiple organ failure. | Lumlertgul, D., et al. 1992. Ren Fail. 14: 77-80. PMID: 1561392
- Amino acid sequence of human histidine-rich glycoprotein derived from the nucleotide sequence of its cDNA. | Koide, T., et al. 1986. Biochemistry. 25: 2220-5. PMID: 3011081
- Evidence for the absence of intron H of the histidine-rich glycoprotein (HRG) gene: genetic mapping and in situ localization of HRG to chromosome 3q28-q29. | Hennis, BC., et al. 1994. Genomics. 19: 195-7. PMID: 8188234
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPRG Antibody (G-10) | sc-398239 | 200 µg/ml | $322.00 | |||
HPRG Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-524259 | 200 µg Ab, 40 µg BP | $361.00 | |||
HPRG Antibody (G-10): m-IgG2b BP-HRP Bundle | sc-549157 | 200 µg Ab; 10 µg BP | $361.00 | |||
HPRG Antibody (G-10) AC | sc-398239 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HPRG Antibody (G-10) HRP | sc-398239 HRP | 200 µg/ml | $322.00 | |||
HPRG Antibody (G-10) FITC | sc-398239 FITC | 200 µg/ml | $336.00 | |||
HPRG Antibody (G-10) PE | sc-398239 PE | 200 µg/ml | $349.00 | |||
HPRG Antibody (G-10) Alexa Fluor® 488 | sc-398239 AF488 | 200 µg/ml | $364.00 | |||
HPRG Antibody (G-10) Alexa Fluor® 546 | sc-398239 AF546 | 200 µg/ml | $364.00 | |||
HPRG Antibody (G-10) Alexa Fluor® 594 | sc-398239 AF594 | 200 µg/ml | $364.00 | |||
HPRG Antibody (G-10) Alexa Fluor® 647 | sc-398239 AF647 | 200 µg/ml | $364.00 | |||
HPRG Antibody (G-10) Alexa Fluor® 680 | sc-398239 AF680 | 200 µg/ml | $364.00 | |||
HPRG Antibody (G-10) Alexa Fluor® 790 | sc-398239 AF790 | 200 µg/ml | $364.00 | |||
HPRG (G-10) Neutralizing Peptide | sc-398239 P | 100 µg/0.5 ml | $69.00 |