HoxA9 Antibody (HOX5I043): sc-81291
- HoxA9 Antibody (HOX5I043) is a mouse monoclonal IgG1 κ HoxA9 antibody, cited in 10 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to the C-terminal region of HoxA9 of human origin
- recommended for detection of HoxA9 of mouse, rat and human origin by WB and IP
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HoxA9 Antibody (HOX5I043) for WB applications. These reagents are now offered in bundles with HoxA9 Antibody (HOX5I043) (see ordering information below).
HoxA9 Antibody (HOX5I043) is a mouse monoclonal IgG1 kappa light chain antibody that detects HoxA9 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). HoxA9 (HOX5I043) antibody is available as a non-conjugated anti-HoxA9 antibody. The HOX homeobox genes encode critical proteins involved in embryonic development, and HOXA9 specifically encodes a class I homeodomain protein expressed in both normal adult and fetal thymic tissue. This expression is vital as HOXA9 plays a significant role in regulating early differentiation of thymocytes, which are essential for developing a functional immune system. HOXA9 homeodomain protein cooperatively binds to consensus DNA sequences alongside Meis1 and Pbx1, forming a complex crucial for gene regulation during hematopoiesis. Notably, HOXA9 dysregulation, particularly with Meis1 and Pbx1, has been implicated in leukemic transformation in both mice and humans. HOXA9 and Meis1 overexpression in primary bone marrow cells induces growth factor-dependent acute myeloid leukemia (AML) in syngeneic mice, highlighting HOXA9′s importance in oncogenesis. Furthermore, chromosomal translocation t(7;11)(p15;p15) has been identified in patients with human AML and chronic myelogenous leukemia (CML), leading to NUP98-HOXA9 fusion gene formation. Mice transplanted with bone marrow cells expressing NUP98-HOXA9 develop a myeloproliferative disease (MPD) that progresses to AML, underscoring HOXA9′s critical role in both normal development and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HoxA9 Antibody (HOX5I043) References:
- NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. | Kroon, E., et al. 2001. EMBO J. 20: 350-61. PMID: 11157742
- Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). | Fujino, T., et al. 2002. Blood. 99: 1428-33. PMID: 11830496
- Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. | Nakamura, T., et al. 1996. Nat Genet. 12: 154-8. PMID: 8563753
- HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. | Taylor, HS., et al. 1998. J Clin Invest. 101: 1379-84. PMID: 9525980
- Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. | Kroon, E., et al. 1998. EMBO J. 17: 3714-25. PMID: 9649441
- Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes. | Izon, DJ., et al. 1998. Blood. 92: 383-93. PMID: 9657735
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HoxA9 Antibody (HOX5I043) | sc-81291 | 100 µg/ml | $339.00 | |||
HoxA9 Antibody (HOX5I043): m-IgG Fc BP-HRP Bundle | sc-537242 | 100 µg Ab; 10 µg BP | $361.00 | |||
HoxA9 Antibody (HOX5I043): m-IgGκ BP-HRP Bundle | sc-534465 | 100 µg Ab; 40 µg BP | $361.00 | |||
HoxA9 Antibody (HOX5I043): m-IgG1 BP-HRP Bundle | sc-545098 | 100 µg Ab; 20 µg BP | $361.00 |