HOOK2 Antibody (D-11): sc-166509

HOOK2 Antibody (D-11) is a mouse monoclonal IgG2b antibody that detects HOOK2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HOOK2, also known as HK2, is a 719 amino acid protein that plays a crucial role in the organization of microtubules and the spatial arrangement of membrane-trafficking systems within cells. HOOK2′s unique structure, characterized by a central coiled-coil domain that facilitates homodimerization, allows HOOK2 to effectively bind to microtubules while HOOK2′s divergent C-terminal domain is responsible for interactions with various organelles. This structural versatility is essential for HOOK2′s function in cellular transport processes, as HOOK2 localizes to specific subcellular structures that are not associated with typical organelles such as endosomes or the Golgi complex. Notably, HOOK2 has been implicated in esophageal cancer, with potential interactions with proteins like SURF1 and Zic2, highlighting HOOK2′s importance in both normal cellular function and disease states. HOOK2 expression is particularly strong in the larynx and esophagus, making anti-HOOK2 antibody (D-11) a valuable tool for researchers studying HOOK2′s role in these tissues and potential as a tumor antigen.

The preferred HOOK2 antibody is HOOK2 Antibody (G-4): sc-365716.