HOOK2 Antibody (A-8): sc-137108

HOOK2 Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects HOOK2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HOOK2 is a crucial member of the HOOK protein family, which plays a significant role in the spatial organization of membrane-trafficking systems by interacting with microtubules and various organelles. HOOK2 is 719 amino acids long and forms homodimers, likely through its central coiled-coil domain, which is essential for structural integrity and function. HOOK2 is involved in organelle binding, and HOOK2 expression is particularly strong in the larynx and esophagus, suggesting a specialized role in these tissues. HOOK2 has been implicated in esophageal cancer, as HOOK2 may associate with other proteins such as SURF1 and Zic2, which are also potential tumor antigens. HOOK2′s unique localization to discrete subcellular structures, distinct from early or late endosomes, mitochondria, the Golgi complex, the endoplasmic reticulum, lysosomes, or multivesicular bodies, highlights HOOK2′s specialized function in cellular organization and trafficking, making anti-HOOK2 antibody (A-8) a valuable tool for research in cancer biology and cellular dynamics.

The preferred HOOK2 antibody is HOOK2 Antibody (G-4): sc-365716.