Homer-3 Antibody (G-2): sc-365254

Homer-3 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects Homer-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Homer-3 is a crucial member of the Homer family of proteins, which are immediate early gene products that play a significant role in synaptic signaling by binding to group 1 metabotropic glutamate receptors (mGluRs). These receptors are essential for triggering intracellular calcium release, a process vital for various neuronal functions, including synaptic plasticity and memory formation. Unlike Homer-1a, which is transiently expressed and does not multimerize, Homer-3 is constitutively expressed and contains a coiled-coil domain that facilitates self-multimerization, allowing Homer-3 to form complexes that stabilize mGluR signaling. Homer-3′s ability to link mGluRs with inositol triphosphate receptors (IP3R) further underscores its importance in intracellular signaling pathways, making Homer-3 a valuable target for research into synaptic function and neurobiology. With robust reactivity and versatility in various applications, anti-Homer-3 antibody (G-2) is an essential tool for researchers investigating the intricate mechanisms of synaptic transmission and plasticity.

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Homer-3 Antibody (G-2) References:

1. A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.  |  Cooper, ST. and Hanson, IM. 2005. BMC Genet. 6: 43. PMID: 16098226
2. Homer 3 autoimmunity in subacute idiopathic cerebellar ataxia.  |  Zuliani, L., et al. 2007. Neurology. 68: 239-40. PMID: 17224583
3. Growth and differentiation effects of Homer3 on a leukemia cell line.  |  Li, Z., et al. 2013. Asian Pac J Cancer Prev. 14: 2525-8. PMID: 23725168
4. Structural and regulatory elements of the interaction between amyloid-β protein precursor and Homer3.  |  Kyratzi, E., et al. 2015. J Alzheimers Dis. 45: 147-57. PMID: 25589726
5. Homer3 regulates the establishment of neutrophil polarity.  |  Wu, J., et al. 2015. Mol Biol Cell. 26: 1629-39. PMID: 25739453
6. Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.  |  Ruegsegger, C., et al. 2016. Neuron. 89: 129-46. PMID: 26748090
7. Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer.  |  Peixoto, A., et al. 2021. J Exp Clin Cancer Res. 40: 191. PMID: 34108014
8. Anti-Homer-3 antibodies in cerebrospinal fluid and serum samples from a 58-year-old woman with subacute cerebellar degeneration and diffuse breast adenocarcinoma.  |  Klötzsch, C., et al. 2022. Neurol Res Pract. 4: 29. PMID: 35871640
9. Case report and literature analysis: Autoimmune cerebellar ataxia associated with homer-3 antibodies.  |  Wu, Q., et al. 2022. Front Neurol. 13: 951659. PMID: 35959384
10. Cerebrospinal Fluid Homer-3 Autoantibodies in a Patient with Amnestic Mild Cognitive Impairment.  |  Hansen, N., et al. 2023. Brain Sci. 13: PMID: 36672107

The preferred Homer antibody is Homer Antibody (D-3): sc-17842.