Homer-3 Antibody (G-2): sc-365254
- Homer-3 Antibody (G-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 337-360 at the C-terminus of Homer-3 of human origin
- recommended for detection of Homer-3a and Homer-3b of mouse, rat and human origin by WB, IP, IF and ELISA
- See Homer (D-3): sc-17842 for Homer-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Homer-3 Antibody (G-2) for WB applications. These reagents are now offered in bundles with Homer-3 Antibody (G-2) (see ordering information below).
Homer-3 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects Homer-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Homer-3 is a crucial member of the Homer family of proteins, which are immediate early gene products that play a significant role in synaptic signaling by binding to group 1 metabotropic glutamate receptors (mGluRs). These receptors are essential for triggering intracellular calcium release, a process vital for various neuronal functions, including synaptic plasticity and memory formation. Unlike Homer-1a, which is transiently expressed and does not multimerize, Homer-3 is constitutively expressed and contains a coiled-coil domain that facilitates self-multimerization, allowing Homer-3 to form complexes that stabilize mGluR signaling. Homer-3′s ability to link mGluRs with inositol triphosphate receptors (IP3R) further underscores its importance in intracellular signaling pathways, making Homer-3 a valuable target for research into synaptic function and neurobiology. With robust reactivity and versatility in various applications, anti-Homer-3 antibody (G-2) is an essential tool for researchers investigating the intricate mechanisms of synaptic transmission and plasticity.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Homer-3 Antibody (G-2) References:
- A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11. | Cooper, ST. and Hanson, IM. 2005. BMC Genet. 6: 43. PMID: 16098226
- Homer 3 autoimmunity in subacute idiopathic cerebellar ataxia. | Zuliani, L., et al. 2007. Neurology. 68: 239-40. PMID: 17224583
- Growth and differentiation effects of Homer3 on a leukemia cell line. | Li, Z., et al. 2013. Asian Pac J Cancer Prev. 14: 2525-8. PMID: 23725168
- Structural and regulatory elements of the interaction between amyloid-β protein precursor and Homer3. | Kyratzi, E., et al. 2015. J Alzheimers Dis. 45: 147-57. PMID: 25589726
- Homer3 regulates the establishment of neutrophil polarity. | Wu, J., et al. 2015. Mol Biol Cell. 26: 1629-39. PMID: 25739453
- Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. | Ruegsegger, C., et al. 2016. Neuron. 89: 129-46. PMID: 26748090
- Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer. | Peixoto, A., et al. 2021. J Exp Clin Cancer Res. 40: 191. PMID: 34108014
- Anti-Homer-3 antibodies in cerebrospinal fluid and serum samples from a 58-year-old woman with subacute cerebellar degeneration and diffuse breast adenocarcinoma. | Klötzsch, C., et al. 2022. Neurol Res Pract. 4: 29. PMID: 35871640
- Case report and literature analysis: Autoimmune cerebellar ataxia associated with homer-3 antibodies. | Wu, Q., et al. 2022. Front Neurol. 13: 951659. PMID: 35959384
- Cerebrospinal Fluid Homer-3 Autoantibodies in a Patient with Amnestic Mild Cognitive Impairment. | Hansen, N., et al. 2023. Brain Sci. 13: PMID: 36672107
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Homer-3 Antibody (G-2) | sc-365254 | 200 µg/ml | $322.00 | |||
Homer-3 Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-537792 | 200 µg Ab; 10 µg BP | $361.00 | |||
Homer-3 Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-535179 | 200 µg Ab; 40 µg BP | $361.00 | |||
Homer-3 Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-545356 | 200 µg Ab; 20 µg BP | $361.00 | |||
Homer-3 (G-2) Neutralizing Peptide | sc-365254 P | 100 µg/0.5 ml | $69.00 |