hnRNP U Antibody (D-2): sc-365852

hnRNP U Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects hnRNP U in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). hnRNP U, also known as SP120 or scaffold attachment factor A, is a crucial component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, playing a significant role in the maturation and transport of heterogeneous nuclear RNA (hnRNA). hnRNP U is predominantly located in the nucleoplasm, where hnRNP U is involved in pre-mRNA processing and directly binds to both RNA and DNA, specifically exhibiting a high affinity for the scaffold attachment region of DNA. hnRNP U localization within the nucleus is vital for function, as hnRNP U facilitates the regulation of gene expression by influencing RNA polymerase II activity. Notably, hnRNP U acts as an inhibitor of RNA polymerase elongation by preventing the phosphorylation of the carboxy-terminal domain of RNA polymerase II by the transcription factor TFIIH, thereby modulating transcriptional regulation. Additionally, hnRNP U interacts with glucocorticoid receptors, similar to GRIP120, to inhibit glucocorticoid induction, highlighting hnRNP U importance in steroid hormone signaling pathways. anti-hnRNP U antibody (D-2) is an essential tool for researchers studying RNA processing and gene regulation mechanisms in various biological contexts.

The preferred hnRNP U antibody is hnRNP U Antibody (3G6): sc-32315.