hnRNP M3/4 Antibody (2A6): sc-20001
- hnRNP M3/4 Antibody (2A6) is a mouse monoclonal IgG1 κ, cited in 19 publications, provided at 200 µg/ml
- raised against fusion protein consisting of entire M4 protein sequence
- recommended for detection of hnRNP M3 and hnRNP M4 of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including and rabbit, bovine and porcine
- See hnRNP M1-4 (1D8): sc-20002 for hnRNP M3/4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for hnRNP M3/4 Antibody (2A6) for WB applications. These reagents are now offered in bundles with hnRNP M3/4 Antibody (2A6) (see ordering information below).
hnRNP M3/4 Antibody (2A6) is a mouse monoclonal IgG1 antibody that detects hnRNP M in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). hnRNP M plays a crucial role in pre-mRNA splicing and is particularly important in the regulation of gene expression under stress conditions, where hnRNP M can induce transient splicing arrest. This function is vital as hnRNP M allows cells to adapt splicing patterns in response to environmental changes, thereby influencing the production of various protein isoforms that can help cells cope with stress. hnRNP M monoclonal antibody (2A6) provides reliable detection of hnRNP M, facilitating studies on mRNA processing and implications in diseases associated with splicing dysregulation. hnRNP M (2A6) antibody is an essential tool for researchers investigating RNA biology and molecular mechanisms underlying cellular responses to stress.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
hnRNP M3/4 Antibody (2A6) References:
- Promoter-Dependent Translation Controlled by p54nrb and hnRNPM during Myoblast Differentiation. | Ainaoui, N., et al. 2015. PLoS One. 10: e0136466. PMID: 26332123
- HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases. | Sun, H., et al. 2017. Genes Chromosomes Cancer. 56: 598-607. PMID: 28393427
- hnRNPM, a potential mediator of YY1 in promoting the epithelial-mesenchymal transition of prostate cancer cells. | Yang, T., et al. 2019. Prostate. 79: 1199-1210. PMID: 31251827
- HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness. | Ho, JS., et al. 2021. Elife. 10: PMID: 34075878
- CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer. | Wang, X., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34385309
- Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma. | Zhu, GQ., et al. 2022. Cell Mol Gastroenterol Hepatol. 13: 1413-1447. PMID: 35158098
- Knockdown of HNRNPM inhibits the progression of glioma through inducing ferroptosis. | Wang, J., et al. 2023. Cell Cycle. 22: 2264-2279. PMID: 38016815
- hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing. | Zheng, R., et al. 2024. Mol Cell. 84: 2087-2103.e8. PMID: 38815579
- PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression. | Lee, YF., et al. 2024. Genome Med. 16: 91. PMID: 39034402
- FMRP protects breast cancer cells from ferroptosis by promoting SLC7A11 alternative splicing through interacting with hnRNPM. | Wang, N., et al. 2024. Redox Biol. 77: 103382. PMID: 39388855
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
hnRNP M3/4 Antibody (2A6) | sc-20001 | 200 µg/ml | $316.00 | |||
hnRNP M3/4 Antibody (2A6): m-IgG Fc BP-HRP Bundle | sc-536638 | 200 µg Ab; 10 µg BP | $354.00 | |||
hnRNP M3/4 Antibody (2A6): m-IgGκ BP-HRP Bundle | sc-533795 | 200 µg Ab; 40 µg BP | $354.00 |