HNF-1β Antibody (94.8): sc-130407

HNF-1β Antibody (94.8) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect the hepatocyte nuclear factor 1-beta (HNF-1β) protein, also known as HNF1B or HNF1 homeobox B. HNF-1β monoclonal antibody (94.8) is raised against recombinant human HNF-1β and is validated for use in western blotting (WB) and immunoprecipitation (IP) applications, ensuring reliable detection in human samples. HNF-1β is a critical transcription factor involved in the regulation of gene expression in various tissues, including the liver, kidney, pancreas, and intestines. The primary function of HNF-1β is to control the transcription of genes essential for cellular differentiation, metabolism, and organ development, making HNF-1β pivotal in maintaining normal physiological processes. Dysregulation or mutations in HNF-1β are associated with several diseases, including diabetes, polycystic kidney disease, and certain cancers, highlighting HNF-1β′s importance in both health and disease. By targeting HNF-1β, anti-HNF-1β antibody (94.8) facilitates advanced research into these pathways and disease mechanisms, providing valuable insights for therapeutic development. HNF-1β monoclonal antibody (94.8) is available in a non-conjugated form, allowing flexibility for various experimental setups. Anti-HNF-1β antibody (94.8) is recommended for scientists studying the intricate roles of HNF-1β in gene regulation and its impact on organ function and disease.

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HNF-1β Antibody (94.8) References:

1. Cystic kidney disease, chromophobe renal cell carcinoma and TCF2 (HNF1 beta) mutations.  |  Lebrun, G., et al. 2005. Nat Clin Pract Nephrol. 1: 115-9. PMID: 16932376
2. Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic development.  |  Edghill, EL., et al. 2006. Diabet Med. 23: 1301-6. PMID: 17116179
3. Specific expression of hepatocyte nuclear factor-1beta in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis.  |  Higashiguchi, A., et al. 2007. Cancer Sci. 98: 387-91. PMID: 17270029
4. Neonatal cholestatic jaundice as the first symptom of a mutation in the hepatocyte nuclear factor-1beta gene (HNF-1beta).  |  Beckers, D., et al. 2007. J Pediatr. 150: 313-4. PMID: 17307554
5. Immunocytochemistry for hepatocyte nuclear factor-1beta (HNF-1beta): a marker for ovarian clear cell carcinoma.  |  Kato, N., et al. 2007. Diagn Cytopathol. 35: 193-7. PMID: 17351940
6. More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.  |  Bach, I. and Yaniv, M. 1993. EMBO J. 12: 4229-42. PMID: 7900999
7. The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution.  |  Kaestner, KH., et al. 1994. Genomics. 20: 377-85. PMID: 8034310
8. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.  |  Drewes, T., et al. 1996. Mol Cell Biol. 16: 925-31. PMID: 8622695
9. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression.  |  Samadani, U. and Costa, RH. 1996. Mol Cell Biol. 16: 6273-84. PMID: 8887657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HNF-1β Antibody (94.8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-HNF-1β Antibody (94.8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HNF-1β Antibody (94.8) Specifications

Alternate Product Name: HNF1B

Product Clone Name: 94.8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 29-118

Epitope Target: HNF-1β

Epitope Species: human

Product Reactivity/Detection: HNF-1β

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for HNF-1β Antibody (94.8): N/A

The preferred HNF-1α antibody is HNF-1α Antibody (F-7): sc-393925.