HLA-DRβ Antibody (7.3.19.1): sc-59261

HLA-DRβ Antibody (7.3.19.1) is a mouse monoclonal IgG2b antibody that detects HLA-DRβ in human samples through immunofluorescence (IF) applications. HLA-DRβ is a critical component of the major histocompatibility complex (MHC) class II molecules, which are essential for the immune system′s ability to present antigens to CD4+ helper T cells. The proper functioning of HLA-DRβ is vital for initiating adaptive immune responses, as HLA-DRβ facilitates the recognition of foreign peptides derived from pathogens, thereby influencing the activation and proliferation of T cells. This process is crucial for the development of effective immune responses and the generation of immunological memory. HLA-DRβ is predominantly located on the surface of antigen-presenting cells, such as B cells, dendritic cells, and macrophages, where HLA-DRβ plays a pivotal role in immune surveillance and response to infections. Various factors, including cytokines, can modulate HLA-DRβ expression, thereby impacting immune response. HLA-DRβ also undergoes post-translational modifications, such as glycosylation, which are important for stability, function, and interactions with other proteins in the immune system. Anti-HLA-DRβ antibody (7.3.19.1) is an invaluable tool for researchers studying immune responses, autoimmune diseases, and the role of MHC class II molecules in health and disease.

The preferred HLA-DRβ antibody is HLA-DRβ Antibody (DA2): sc-53314.