HLA-DR Antibody (SPM289): sc-56545

HLA-DR Antibody (SPM289) is a mouse monoclonal IgG2b kappa light chain antibody, engineered to target the HLA-DR protein, also known as Human Leukocyte Antigen-DR or MHC class II DR isotype. Anti-HLA-DR antibody (SPM289) recognizes an epitope present on activated peripheral blood mononuclear cells of human origin and exhibits cross-reactivity with HLA-DR proteins from mouse, rat, and human species. HLA-DR protein is a critical component of the Major Histocompatibility Complex (MHC) class II molecules, which are heterodimers composed of alpha and beta chains. The structural integrity of HLA-DR, particularly its peptide-binding groove, is essential for the accurate presentation of exogenous peptides to CD4+ helper T cells, thereby initiating and regulating immune responses. Anti-HLA-DR antibody (SPM289) is recommended for use in various applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM), ensuring reliable performance across diverse experimental setups. The ability of HLA-DR monoclonal antibody (SPM289) to bind to multiple species makes this reagent a versatile tool for comparative studies in immunology and related fields. By targeting HLA-DR, anti-HLA-DR antibody (SPM289) facilitates the investigation of immune mechanisms, autoimmune disease susceptibility, and therapeutic antibody development.

The preferred HLA-DR antibody is HLA-DR Antibody (L243): sc-18875.