HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1): sc-53311
- HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) is a mouse monoclonal IgG2b κ HLA-DQ3/DQ4/DR4 antibody provided at 200 µg/ml
- raised against HLA-DQ of human origin
- HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) is recommended for detection of HLA-DQ3/DQ4/DR4 of human origin by WB and FCM
- Anti-HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) for WB applications. These reagents are now offered in bundles with HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) (see ordering information below).
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) is a mouse monoclonal IgG2b kappa light chain antibody that detects the HLA-DQ3/DQ4/DR4 protein of human origin by western blotting (WB) and flow cytometry (FCM). Anti-HLA-DQ3/DQ4/DR4 antibody (TAL 12.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HLA-DQ3/DQ4/DR4 is a crucial component of the major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune system by presenting processed antigens to CD4+ T lymphocytes. This interaction is essential for the activation of T cells, which are pivotal in orchestrating the immune response against pathogens. HLA-DQ and HLA-DR molecules are particularly important in the context of autoimmune diseases and transplant rejection, as these proteins can influence the recognition of self versus non-self antigens. The polymorphic nature of HLA-DQ3/DQ4/DR4 allows for a diverse range of antigen presentation, which is critical for effective immune surveillance. Using HLA-DQ3/DQ4/DR4 (TAL 12.1) antibody enables researchers to gain insights into the mechanisms of immune response and the role of these antigens in various diseases, making this tool invaluable for both basic and clinical research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) References:
- HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis. | van der Horst-Bruinsma, IE., et al. 1999. Hum Immunol. 60: 152-8. PMID: 10027783
- Sequences and factors: a guide to MHC class-II transcription. | Glimcher, LH. and Kara, CJ. 1992. Annu Rev Immunol. 10: 13-49. PMID: 1590984
- MHC class-II molecules and autoimmunity. | Nepom, GT. and Erlich, H. 1991. Annu Rev Immunol. 9: 493-525. PMID: 1910687
- Monoclonal antibodies and the epitope distribution of HLA class II polymorphisms. | Bodmer, JG., et al. 1989. Cold Spring Harb Symp Quant Biol. 54 Pt 1: 471-6. PMID: 2484167
- HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. | Hirayama, K., et al. Nature. 327: 426-30. PMID: 3108669
- Assembly, transport, and function of MHC class II molecules. | Cresswell, P. 1994. Annu Rev Immunol. 12: 259-93. PMID: 8011283
- HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity. | Apple, RJ., et al. 1994. Nat Genet. 6: 157-62. PMID: 8162070
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) | sc-53311 | 200 µg/ml | $322.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1): m-IgG Fc BP-HRP Bundle | sc-525587 | 200 µg Ab; 10 µg BP | $361.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1): m-IgG2b BP-HRP Bundle | sc-549589 | 200 µg Ab; 10 µg BP | $361.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) AC | sc-53311 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) HRP | sc-53311 HRP | 200 µg/ml | $322.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) FITC | sc-53311 FITC | 200 µg/ml | $336.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) PE | sc-53311 PE | 200 µg/ml | $349.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) Alexa Fluor® 488 | sc-53311 AF488 | 200 µg/ml | $364.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) Alexa Fluor® 546 | sc-53311 AF546 | 200 µg/ml | $364.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) Alexa Fluor® 594 | sc-53311 AF594 | 200 µg/ml | $364.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) Alexa Fluor® 647 | sc-53311 AF647 | 200 µg/ml | $364.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) Alexa Fluor® 680 | sc-53311 AF680 | 200 µg/ml | $364.00 | |||
HLA-DQ3/DQ4/DR4 Antibody (TAL 12.1) Alexa Fluor® 790 | sc-53311 AF790 | 200 µg/ml | $364.00 |