HIV-1 Rev Antibody (Rev-4): sc-69729
- HIV-1 Rev Antibody (Rev-4) is a mouse monoclonal IgG1 κ HIV-1 Rev antibody, cited in 7 publications, provided at 200 µg/ml
- raised against HIV-1 Rev
- HIV-1 Rev Antibody (Rev-4) is recommended for detection of Rev of HIV-1 origin by WB, IP and IF
- Anti-HIV-1 Rev Antibody (Rev-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HIV-1 Rev Antibody (Rev-4) for WB applications. These reagents are now offered in bundles with HIV-1 Rev Antibody (Rev-4) (see ordering information below).
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HIV-1 Rev Antibody (Rev-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects HIV-1 Rev protein of HIV-1 origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-HIV-1 Rev antibody (Rev-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. HIV-1 Rev protein plays a crucial role in the viral life cycle by facilitating the export of unspliced and partially spliced viral mRNAs from the nucleus to cytoplasm, which is essential for viral protein production and new virion assembly. This function allows HIV-1 to bypass host cell splicing machinery, ensuring efficient synthesis of necessary components for viral replication. HIV-1 Rev protein interacts with the Rev response element (RRE) in viral RNA, highlighting its significance in regulating gene expression during HIV-1 infection. Understanding HIV-1 Rev mechanisms is vital for developing therapeutic strategies aimed at inhibiting viral replication and combating HIV-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HIV-1 Rev Antibody (Rev-4) References:
- HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process. | Gallo, SA., et al. 2001. Biochemistry. 40: 12231-6. PMID: 11591141
- Specific antibody responses to synthetic peptides of HIV-1 p17 correlate with different stages of HIV-1 infection. | Jiang, JD., et al. 1992. J Acquir Immune Defic Syndr (1988). 5: 382-90. PMID: 1372353
- Immune response and epitope mapping of a candidate HIV-1 p17 vaccine HGP30. | Boucher, CA., et al. 1990. J Clin Lab Anal. 4: 43-7. PMID: 1690277
- HIV-1 p17 synthetic peptide vaccine HGP-30: induction of immune response in human subjects and preliminary evidence of protection against HIV challenge in SCID mice. | Sarin, PS., et al. 1995. Cell Mol Biol (Noisy-le-grand). 41: 401-7. PMID: 7580834
- A longitudinal study of the IgG antibody response to HIV-1 p17 gag protein in HIV-1+ patients with haemophilia: titre and avidity. | Chargelegue, D., et al. 1993. Clin Exp Immunol. 93: 331-6. PMID: 8370162
- [HIV-1 p17 matrix protein is transported into the cell nucleus and binds with genomic viral RNA]. | Bukrinskaia, AG., et al. 1993. Mol Biol (Mosk). 27: 49-57. PMID: 8483474
- Antibodies to the HIV-1 p17 protein cross-react with human superoxide dismutase-2. | Kato, T., et al. 1997. Biochem Biophys Res Commun. 230: 184-7. PMID: 9020042
- Antigenic characterization of HIV-1 gp41 binding proteins. | Chen, YH., et al. 1998. Immunol Lett. 62: 75-9. PMID: 9698101
- Immunodominant epitopes of HIV-1 p17 and p24. | Graham, S., et al. 1992. AIDS Res Hum Retroviruses. 8: 1781-8. PMID: 1280955
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIV-1 Rev Antibody (Rev-4) | sc-69729 | 200 µg/ml | $316.00 | |||
HIV-1 Rev Antibody (Rev-4): m-IgG Fc BP-HRP Bundle | sc-526983 | 200 µg Ab; 10 µg BP | $354.00 | |||
HIV-1 Rev Antibody (Rev-4): m-IgG1 BP-HRP Bundle | sc-532356 | 200 µg Ab; 20 µg BP | $354.00 | |||
HIV-1 Rev Antibody (Rev-4) AC | sc-69729 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HIV-1 Rev Antibody (Rev-4) HRP | sc-69729 HRP | 200 µg/ml | $316.00 | |||
HIV-1 Rev Antibody (Rev-4) FITC | sc-69729 FITC | 200 µg/ml | $330.00 | |||
HIV-1 Rev Antibody (Rev-4) PE | sc-69729 PE | 200 µg/ml | $343.00 | |||
HIV-1 Rev Antibody (Rev-4) Alexa Fluor® 488 | sc-69729 AF488 | 200 µg/ml | $357.00 | |||
HIV-1 Rev Antibody (Rev-4) Alexa Fluor® 546 | sc-69729 AF546 | 200 µg/ml | $357.00 | |||
HIV-1 Rev Antibody (Rev-4) Alexa Fluor® 594 | sc-69729 AF594 | 200 µg/ml | $357.00 | |||
HIV-1 Rev Antibody (Rev-4) Alexa Fluor® 647 | sc-69729 AF647 | 200 µg/ml | $357.00 | |||
HIV-1 Rev Antibody (Rev-4) Alexa Fluor® 680 | sc-69729 AF680 | 200 µg/ml | $357.00 | |||
HIV-1 Rev Antibody (Rev-4) Alexa Fluor® 790 | sc-69729 AF790 | 200 µg/ml | $357.00 |