HIV-1 gp41 Antibody (1911): sc-58148
- HIV-1 gp41 Antibody (1911) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against Human Immunodeficiency Virus1
- recommended for detection of gp41 envelope glycoprotein of HIV-1 origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HIV-1 gp41 Antibody (1911). This work is in progress.
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HIV-1 gp41 Antibody (1911) is a mouse monoclonal IgG2a antibody that specifically detects HIV-1 gp41 by western blotting (WB). HIV-1 gp41 is a crucial glyco-envelope protein that plays a significant role in the viral life cycle, particularly in fusion of the viral envelope with host cell membrane, essential for viral entry into target cells. This process enables viral infection of helper T cells, B cells, and monocytes, ultimately leading to HIV infection progression and acquired immune deficiency syndrome (AIDS) development. gp41 contains a hydrophobic fusion peptide that facilitates viral and cellular membrane merging, critical for successful viral genome delivery into host cells. Understanding HIV-1 gp41 function and structure aids in therapeutic strategy and vaccine development while providing insights into viral pathogenesis mechanisms. anti-HIV-1 gp41 antibody (1911) serves as an invaluable tool for researchers studying HIV-1 biology and immune response to infection.
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HIV-1 gp41 Antibody (1911) References:
- HIV-1 gp41 and type I interferon: sequence homology and biological as well as clinical implications. | Chen, YH., et al. 2000. Immunol Res. 22: 61-6. PMID: 10945227
- HIV-1 gp41 heptad repeat 2 (HR2) possesses an amino acid domain that resembles the allergen domain in Aspergillus fumigatus Asp f1 protein: review, hypothesis and implications. | Becker, Y. 2007. Virus Genes. 34: 233-40. PMID: 17333401
- Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. | Liao, HX., et al. 2011. J Exp Med. 208: 2237-49. PMID: 21987658
- HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. | Yates, NL., et al. 2013. Mucosal Immunol. 6: 692-703. PMID: 23299618
- Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. | Bradley, T., et al. 2016. EBioMedicine. 12: 196-207. PMID: 27612593
- A novel HIV-1 gp41 tripartite model for rational design of HIV-1 fusion inhibitors with improved antiviral activity. | Su, S., et al. 2017. AIDS. 31: 885-894. PMID: 28121713
- Evaluation of sequence variability in HIV-1 gp41 C-peptide helix-grafted proteins. | Tennyson, RL., et al. 2018. Bioorg Med Chem. 26: 1220-1224. PMID: 28811070
- Cloning, expression and nanodiscs assemble of recombinant HIV-1 gp41. | Elbahnasawy, MA., et al. 2020. Microb Pathog. 138: 103824. PMID: 31669502
- Real-time Exchange of the Lipid-bound Intermediate and Post-fusion States of the HIV-1 gp41 Ectodomain. | Chiliveri, SC., et al. 2022. J Mol Biol. 434: 167683. PMID: 35700771
- Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies. | Bruun, TUJ., et al. 2023. J Biol Chem. 299: 103062. PMID: 36841484
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIV-1 gp41 Antibody (1911) | sc-58148 | 100 µg/ml | $316.00 |