HIV-1 gp41 Antibody (10E9): sc-57812

HIV-1 gp41 Antibody (10E9) is a mouse monoclonal IgG1 antibody that detects HIV-1 gp41 protein of HIV-1 origin by western blotting (WB) and immunofluorescence (IF). Anti-HIV-1 gp41 antibody (10E9) is available as the non-conjugated monoclonal isotype antibody. HIV-1 gp41 plays a crucial role in the viral life cycle, particularly in the fusion of the viral envelope with the host cell membrane, which is essential for viral entry into target cells. This process allows the virus to infect key immune cells, such as CD4+ T cells, which are critical for orchestrating the immune response. By facilitating the entry of HIV-1 into these cells, gp41 contributes to the virus′s ability to evade the immune system and establish a persistent infection, ultimately leading to the development of acquired immune deficiency syndrome (AIDS). Understanding HIV-1 gp41 function is important for developing therapeutic strategies aimed at blocking viral entry and preventing the progression of HIV infection.

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HIV-1 gp41 Antibody (10E9) References:

1. HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process.  |  Gallo, SA., et al. 2001. Biochemistry. 40: 12231-6. PMID: 11591141
2. Immunodominant epitopes of HIV-1 p17 and p24.  |  Graham, S., et al. 1992. AIDS Res Hum Retroviruses. 8: 1781-8. PMID: 1280955
3. Specific antibody responses to synthetic peptides of HIV-1 p17 correlate with different stages of HIV-1 infection.  |  Jiang, JD., et al. 1992. J Acquir Immune Defic Syndr (1988). 5: 382-90. PMID: 1372353
4. Immune response and epitope mapping of a candidate HIV-1 p17 vaccine HGP30.  |  Boucher, CA., et al. 1990. J Clin Lab Anal. 4: 43-7. PMID: 1690277
5. Targeting HIV-1 gp41-induced fusion and pathogenesis for anti-viral therapy.  |  Garg, H., et al. 2011. Curr Top Med Chem. 11: 2947-58. PMID: 22044225
6. Synthesized peptide inhibitors of HIV-1 gp41-dependent membrane fusion.  |  He, Y. 2013. Curr Pharm Des. 19: 1800-9. PMID: 23092277
7. Neutralizing Antibodies Targeting HIV-1 gp41.  |  Caillat, C., et al. 2020. Viruses. 12: PMID: 33114242
8. HIV-1 p17 synthetic peptide vaccine HGP-30: induction of immune response in human subjects and preliminary evidence of protection against HIV challenge in SCID mice.  |  Sarin, PS., et al. 1995. Cell Mol Biol (Noisy-le-grand). 41: 401-7. PMID: 7580834
9. A longitudinal study of the IgG antibody response to HIV-1 p17 gag protein in HIV-1+ patients with haemophilia: titre and avidity.  |  Chargelegue, D., et al. 1993. Clin Exp Immunol. 93: 331-6. PMID: 8370162
10. [HIV-1 p17 matrix protein is transported into the cell nucleus and binds with genomic viral RNA].  |  Bukrinskaia, AG., et al. 1993. Mol Biol (Mosk). 27: 49-57. PMID: 8483474
11. Antibodies to the HIV-1 p17 protein cross-react with human superoxide dismutase-2.  |  Kato, T., et al. 1997. Biochem Biophys Res Commun. 230: 184-7. PMID: 9020042
12. Antigenic characterization of HIV-1 gp41 binding proteins.  |  Chen, YH., et al. 1998. Immunol Lett. 62: 75-9. PMID: 9698101

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIV-1 gp41 Antibody (10E9) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIV-1 gp41 Antibody (10E9) Specifications

Alternate Product Name: HIV-1 gp41

Product Clone Name: 10E9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HIV-1 gp41

Epitope Species: HIV-1

Product Reactivity/Detection: gp41 envelope glycoprotein

Species Reactivity/Detection: HIV-1

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for HIV-1 gp41 Antibody (10E9): N/A