HIV-1 gp120 Antibody (HIV1gp120): sc-57810

HIV-1 gp120 Antibody (HIV1gp120) is a mouse monoclonal IgG1 antibody that detects HIV-1 gp120 envelope glycoprotein by enzyme-linked immunosorbent assay (ELISA). Anti-HIV-1 gp120 antibody (HIV1gp120) is available in a non-conjugated form, making it suitable for various experimental applications. The gp120 protein plays a crucial role in the HIV-1 lifecycle, as gp120 is responsible for the initial attachment of the virus to host cells, specifically by binding to the CD4 receptor on helper T cells. This interaction is not only vital for viral entry but also serves as a target for neutralizing antibodies, making gp120 a key focus in HIV vaccine development. The structure of gp120 is particularly important because gp120 undergoes conformational changes upon CD4 binding, which exposes additional sites for co-receptor binding and subsequent membrane fusion. Understanding these structural dynamics is essential for designing effective therapeutic strategies and vaccines against HIV-1, as these dynamics highlight potential vulnerabilities in the virus that can be exploited by the immune system. The nomenclature of the gp proteins, including gp120, reflects their molecular weights, with gp120 being derived from the larger gp160 precursor, which is cleaved during viral maturation.

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HIV-1 gp120 Antibody (HIV1gp120) References:

1. The HIV-1 gp120 V1V2 loop: structure, function and importance for vaccine development.  |  O'Connell, RJ., et al. 2014. Expert Rev Vaccines. 13: 1489-500. PMID: 25163695
2. Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806.  |  Liu, T., et al. 2014. Eur J Med Chem. 86: 481-90. PMID: 25203778
3. HIV-1 gp120-Mediated Mitochondrial Dysfunction and HIV-Associated Neurological Disorders.  |  Shah, A. and Kumar, A. 2016. Neurotox Res. 30: 135-7. PMID: 27072361
4. Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function.  |  Hijmans, JG., et al. 2019. J Appl Physiol (1985). 126: 1242-1249. PMID: 30789287
5. NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.  |  He, X., et al. 2020. Cell Mol Immunol. 17: 283-299. PMID: 31320730
6. HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells.  |  Datta, G., et al. 2019. Front Cell Neurosci. 13: 329. PMID: 31379513
7. HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein.  |  Shrestha, J., et al. 2022. Front Aging Neurosci. 14: 811481. PMID: 35615594
8. HIV-1 gp120 Protein Activates Cyclin-Dependent Kinase 1, a Possible Link to Central Nervous System Cell Death.  |  Saro, A., et al. 2022. Viruses. 14: PMID: 36560797
9. Study on molecular mechanisms of CD4 dependency and independency of HIV-1 gp120.  |  Liu, MT., et al. 2023. RSC Adv. 13: 6274-6286. PMID: 36825290
10. HIV-1 gp120 protein promotes HAND through the calcineurin pathway activation.  |  Shrestha, J., et al. 2023. Mitochondrion. 70: 31-40. PMID: 36925028

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIV-1 gp120 Antibody (HIV1gp120) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIV-1 gp120 Antibody (HIV1gp120) Specifications

Alternate Product Name: HIV-1 gp120

Product Clone Name: HIV1gp120

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: gp120

Epitope Species: HIV-1

Product Reactivity/Detection: gp120 envelope glycoprotein

Species Reactivity/Detection: HIV-1

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HIV-1 gp120 Antibody (HIV1gp120): N/A