Histone H2B Antibody (A-6): sc-515808

Histone H2B Antibody (A-6) is a mouse monoclonal IgM antibody that detects Histone H2B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Histone H2B antibody (A-6) is available in a non-conjugated form, allowing for versatile experimental use. Histone H2B plays a crucial role in the structural organization of chromatin, as Histone H2B is one of the core components of the nucleosome, which is essential for DNA packaging within the nucleus. The nucleosome structure, consisting of an octamer formed by two H2A-H2B dimers and two H3-H4 dimers, allows for the compaction of DNA into a more manageable form, facilitating processes such as transcription, replication, and repair. Histone H2B is vital for maintaining genomic stability and regulating gene expression, as alterations in histone composition or modifications can lead to significant cellular consequences, including the development of various diseases. Additionally, Histone H2B undergoes numerous post-translational modifications, such as acetylation and methylation, which influence DNA interaction and other nuclear proteins, thereby impacting chromatin dynamics and cellular function.

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Histone H2B Antibody (A-6) References:

1. Do protein motifs read the histone code?  |  de la Cruz, X., et al. 2005. Bioessays. 27: 164-75. PMID: 15666348
2. The dynamics of histone H1 function in chromatin.  |  Bustin, M., et al. 2005. Mol Cell. 17: 617-20. PMID: 15749012
3. Inducible covalent posttranslational modification of histone H3.  |  Bode, AM. and Dong, Z. 2005. Sci STKE. 2005: re4. PMID: 15855410
4. Regulation of histone synthesis and nucleosome assembly.  |  Gunjan, A., et al. 2005. Biochimie. 87: 625-35. PMID: 15989979
5. The diverse functions of histone lysine methylation.  |  Martin, C. and Zhang, Y. 2005. Nat Rev Mol Cell Biol. 6: 838-49. PMID: 16261189
6. Gene regulation by histone H1: new links to DNA methylation.  |  Rupp, RA. and Becker, PB. 2005. Cell. 123: 1178-9. PMID: 16377556
7. Histone post-translational modifications and the response to DNA double-strand breaks.  |  Wurtele, H. and Verreault, A. 2006. Curr Opin Cell Biol. 18: 137-44. PMID: 16487697
8. Histone modifications: signalling receptors and potential elements of a heritable epigenetic code.  |  Nightingale, KP., et al. 2006. Curr Opin Genet Dev. 16: 125-36. PMID: 16503131
9. Histone H3 variants and their potential role in indexing mammalian genomes: the 'H3 barcode hypothesis'.  |  Hake, SB. and Allis, CD. 2006. Proc Natl Acad Sci U S A. 103: 6428-35. PMID: 16571659
10. Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.  |  Meng, Z., et al. 2023. J Mol Cell Cardiol. 182: 1-14. PMID: 37437402
11. hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under mitochondrial stress.  |  Zhao, L., et al. 2025. Cell Death Differ. 32: 118-133. PMID: 38898233
12. Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, against MASLD Progression.  |  Akl, MG., et al. 2024. Int J Mol Sci. 25: PMID: 39125617

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone H2B Antibody (A-6) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone H2B Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone H2B Antibody (A-6) Specifications

Alternate Product Name: H2B Histone cluster

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1-126

Epitope Target: Histone H2B

Epitope Species: human

Product Reactivity/Detection: Histone H2B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for Histone H2B Antibody (A-6): N/A