Histone H2B Inhibitors
The class of chemicals known as Histone H2B inhibitors presents a diverse spectrum of compounds that intricately modulate the activity of Histone H2B, a pivotal player in chromatin structure, gene regulation, and DNA packaging. This group of compounds offers a nuanced understanding of the regulatory processes involved in controlling Histone H2B and its impact on cellular processes. Rocilinostat and Trichostatin A emerge as direct inhibitors within this class, both targeting histone deacetylases (HDACs). By doing so, they induce hyperacetylation of Histone H2B, leading to alterations in chromatin structure. The direct modulation of Histone H2B by these inhibitors highlights the significance of acetylation in chromatin remodeling and gene expression regulation. Curcumin and JQ1, on the other hand, exert their influence on Histone H2B indirectly through the modulation of signaling pathways. Curcumin, a natural polyphenol, acts on the NF-κB and PI3K/AKT pathways. This dual impact suggests a potential cascade effect on the expression of genes involved in chromatin remodeling, indirectly affecting the function of Histone H2B. JQ1, a bromodomain inhibitor, disrupts the binding of bromodomains to acetylated histones, indirectly influencing the chromatin state and, consequently, the function of Histone H2B.
GSK343 and EPZ-6438 carve out a distinct niche within the Histone H2B inhibitor class by specifically targeting the histone lysine methyltransferase EZH2. By disrupting the trimethylation of histone H3 lysine 27 (H3K27me3), they indirectly influence the chromatin state and function of Histone H2B. This targeted approach emphasizes the importance of histone modifications in orchestrating chromatin dynamics and gene regulation. Nicotinamide, MS-275, Scriptaid, Tubastatin A, and UNC1999 add further layers of complexity to the regulatory mechanisms governing Histone H2B. These compounds modulate Histone H2B by targeting HDACs or histone lysine methyltransferases, inducing hyperacetylation or disrupting histone methylation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ACY-1215 | 1316214-52-4 | sc-507455 | 25 mg | $110.00 | ||
Rocilinostat is a selective inhibitor of histone deacetylase (HDAC) enzymes, including HDAC1 and HDAC2. By inhibiting HDACs, Rocilinostat induces histone acetylation, leading to altered chromatin structure and potential inhibition of Histone H2B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, affects various signaling pathways, including NF-κB and PI3K/AKT. Through these pathways, it modulates the expression of genes involved in chromatin remodeling and can potentially influence Histone H2B, contributing to its inhibition. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a selective inhibitor of bromodomain-containing proteins, including those associated with acetylated histones. By disrupting the binding of bromodomains to acetylated histones, JQ1 can potentially affect the chromatin structure, leading to indirect inhibition of Histone H2B. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $148.00 $452.00 | 1 | |
GSK343 is a specific inhibitor of the histone lysine methyltransferase (HMT) EZH2. By inhibiting EZH2, GSK343 disrupts the trimethylation of histone H3 lysine 27 (H3K27me3), which may indirectly influence the chromatin state and impact the function of Histone H2B. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is an inhibitor of the NAD+-dependent class III HDACs, also known as sirtuins. By inhibiting sirtuins, nicotinamide modulates histone acetylation levels, potentially impacting the chromatin structure and function of Histone H2B. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin is a specific inhibitor of the histone lysine methyltransferase (HMT) SUV39H1. By inhibiting SUV39H1, Chaetocin disrupts the trimethylation of histone H3 lysine 9 (H3K9me3), potentially influencing the chromatin state and function of Histone H2B. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a selective inhibitor of class I HDACs, including HDAC1 and HDAC3. By inhibiting these HDACs, MS-275 induces histone hyperacetylation, leading to altered chromatin structure and potential modulation of Histone H2B function. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is a selective inhibitor of the histone lysine methyltransferase (HMT) EZH2. By inhibiting EZH2, EPZ-6438 disrupts the trimethylation of histone H3 lysine 27 (H3K27me3), potentially influencing the chromatin state and impacting the function of Histone H2B. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $63.00 $179.00 | 11 | |
Scriptaid is an HDAC inhibitor that induces hyperacetylation of histones. By inhibiting HDACs, Scriptaid alters chromatin structure, potentially affecting the function of Histone H2B. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is a specific inhibitor of the histone lysine methyltransferase (HMT) EZH2. By inhibiting EZH2, UNC1999 disrupts the trimethylation of histone H3 lysine 27 (H3K27me3), potentially influencing the chromatin state and impacting the function of Histone H2B. | ||||||