HGTD-P Antibody (E-8): sc-514389

HGTD-P Antibody (E-8) is a mouse monoclonal IgG2b antibody that detects HGTD-P in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HGTD-P, also known as E2IG5 or FAM162A, is a 154 amino acid single-pass membrane protein that plays a crucial role as a proapoptotic factor, particularly in hypoxia-ischemia (HI). HGTD-P is primarily localized to mitochondria, where HGTD-P is instrumental in mediating cell death pathways. HGTD-P′s mitochondrial localization enables induction of mitochondrial permeability transition, a critical event leading to cytochrome c release and subsequent activation of caspase 9, facilitating apoptotic cell death. HGTD-P is regulated by hypoxia-inducible factor 1-alpha (HIF-1α), which binds to a hypoxia-responsive element in HGTD-P promoter, highlighting HGTD-P′s role in cellular responses to low oxygen conditions. HGTD-P (E-8) antibody serves as an essential tool for researchers investigating mechanisms of apoptosis and potential therapeutic targets for HI-induced brain damage.

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HGTD-P Antibody (E-8) References:

1. Proapoptotic role of human growth and transformation-dependent protein in the developing rat brain after hypoxia-ischemia.  |  Qu, Y., et al. 2009. Stroke. 40: 2843-8. PMID: 19520982
2. Expression and clinicopathological significance of human growth and transformation-dependent protein (HGTD-P) in uterine cervical cancer.  |  Cho, YE., et al. 2010. Histopathology. 57: 479-82. PMID: 20840676
3. Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.  |  Polimanti, R., et al. 2017. Am J Med Genet B Neuropsychiatr Genet. 174: 846-853. PMID: 28990359
4. Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma.  |  Dao Trong, P., et al. 2018. Int J Mol Sci. 19: PMID: 30257451
5. Integrated Analysis of Weighted Gene Coexpression Network Analysis Identifying Six Genes as Novel Biomarkers for Alzheimer's Disease.  |  Zhang, T., et al. 2021. Oxid Med Cell Longev. 2021: 9918498. PMID: 34367470
6. Identification and validation of a glycolysis-related gene signature for depicting clinical characteristics and its relationship with tumor immunity in patients with colon cancer.  |  Liu, G., et al. 2022. Aging (Albany NY). 14: 8700-8718. PMID: 35963622
7. Identification of risk model based on glycolysis-related genes in the metastasis of osteosarcoma.  |  Huang, W., et al. 2022. Front Endocrinol (Lausanne). 13: 1047433. PMID: 36387908
8. Exploring the potential link between MitoEVs and the immune microenvironment of periodontitis based on machine learning and bioinformatics methods.  |  Yang, H., et al. 2024. BMC Oral Health. 24: 169. PMID: 38308306
9. A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma.  |  Wang, Y., et al. 2024. Front Immunol. 15: 1467052. PMID: 39569192
10. Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions.  |  Schuhmann, F., et al. 2025. Angew Chem Int Ed Engl. 64: e202417804. PMID: 39644219

The preferred HGTD-P antibody is HGTD-P Antibody (H-4): sc-514243.