HES1 Antibody (F-10): sc-165996
- HES1 Antibody (F-10) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 163-194 of HES1 of human origin
- recommended for detection of HES1 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-165996 X, 200 µg/0.1 ml)
- See HES1 (E-5): sc-166410 for HES1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for HES1 Antibody (F-10) for WB applications. This reagent is now offered in a bundle with HES1 Antibody (F-10) (see ordering information below).
HES1 Antibody (F-10) is a mouse monoclonal IgG2b antibody that detects HES1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HES1 is a crucial transcriptional repressor that plays a significant role in the regulation of myogenesis and neurogenesis, processes essential for proper embryonic development and tissue differentiation. HES1 is primarily located in the nucleus, where HES1 binds to specific DNA sequences to modulate gene expression, thereby influencing cell fate decisions during development. The ability of HES1 to form complexes with TLE proteins, which are the mammalian homologs of the Drosophila Groucho protein, is vital for its function; this interaction is facilitated by the carboxy-terminal WRPW motif of HES proteins. By directly binding to the N box (CACNAG) rather than interfering with activator proteins, HES1 effectively represses target genes, ensuring the precise timing and pattern of gene expression necessary for normal development. The expression of HES1 and HES1 family members in various adult and embryonic tissues underscores their importance in maintaining cellular homeostasis and responding to developmental cues. Anti-HES1 antibody (F-10) is an invaluable tool for researchers studying the intricate mechanisms of gene regulation and the pathways involved in development and differentiation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HES1 Antibody (F-10) | sc-165996 | 200 µg/ml | $322.00 | |||
HES1 Antibody (F-10): m-IgG Fc BP-HRP Bundle | sc-539982 | 200 µg Ab; 10 µg BP | $361.00 | |||
HES1 Antibody (F-10) X | sc-165996 X | 200 µg/0.1 ml | $322.00 |