Hep B cAg Antibody (13A9): sc-23946

Hep B cAg Antibody (13A9) is a mouse monoclonal IgG2b antibody that detects Hep B cAg protein of Hepatitis B by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Hep B cAg plays a crucial role in the life cycle of the Hepatitis B virus, as Hep B cAg encapsulates the viral genome and forms the core of the virus, which is essential for assembly and stability. Understanding the structure of Hep B cAg is vital because Hep B cAg not only aids in the diagnosis of Hepatitis B infection but also provides insights into potential therapeutic targets. The presence of Hep B cAg in the serum indicates active viral replication, making Hep B cAg a key marker for monitoring disease progression and treatment efficacy. Hep B cAg is primarily expressed in liver cells, where the virus replicates, highlighting the importance of liver health in the context of Hepatitis B infection. Anti-Hep B cAg antibody (13A9) enables researchers to effectively study viral dynamics and interactions within the host, contributing to the development of better diagnostic and therapeutic strategies against Hepatitis B.

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Hep B cAg Antibody (13A9) References:

1. Ubiquitin-hepatitis B core antigen-cytoplasmic transduction peptide enhances HBV-specific humoral and CTL immune responses in vivo.  |  Song, L., et al. 2014. Int Immunopharmacol. 23: 1-7. PMID: 25135878
2. Hepatitis B Virus Core Antigen Stimulates IL-6 Expression via p38, ERK and NF-κB Pathways in Hepatocytes.  |  Chen, Z., et al. 2017. Cell Physiol Biochem. 41: 91-100. PMID: 28214858
3. Hepatitis B Core Antigen in Hepatocytes of Chronic Hepatitis B: Comparison between Indirect Immunofluorescence and Immunoperoxidase Method.  |  Raihan, R., et al. 2015. Euroasian J Hepatogastroenterol. 5: 7-10. PMID: 29201677
4. Hepatitis B core antigen regulates dendritic cell proliferation and apoptosis through regulation of PKC/NF‑κB signaling pathway.  |  Liu, L., et al. 2018. Mol Med Rep. 18: 5726-5732. PMID: 30365118
5. Hepatitis B core antigen can regulate NLRP3 inflammasome pathway in HepG2 cells.  |  Ding, X., et al. 2019. J Med Virol. 91: 1528-1536. PMID: 31017673
6. Moving towards core antigen for the management of patients with overt and occult HBV infection.  |  Armandi, A., et al. 2021. Panminerva Med. 63: 499-507. PMID: 33073556
7. Dual-Antigen-Loaded Hepatitis B Virus Core Antigen Virus-like Particles Stimulate Efficient Immunotherapy Against Melanoma.  |  Cheng, K., et al. 2020. ACS Appl Mater Interfaces. 12: 53682-53690. PMID: 33205941
8. Preparation and preliminary evaluation of hepatitis B core antigen virus like nanoparticles loaded with indocyanine green.  |  Wang, Y., et al. 2020. Ann Transl Med. 8: 1661. PMID: 33490173
9. Antibody to hepatitis B virus core antigen positivity is a predictor of non-alcoholic fatty liver disease severity.  |  Saitta, C., et al. 2022. Intern Emerg Med. 17: 1609-1616. PMID: 35332431
10. Levels of Antibodies to Hepatitis B Core Antigen Are Associated With Liver Inflammation and Response to Peginterferon in Patients With Chronic Hepatitis B.  |  Brakenhoff, SM., et al. 2022. J Infect Dis. 227: 113-122. PMID: 35599306

The preferred Hep B cAg antibody is Hep B cAg Antibody (C1-5): sc-23945.