Hep B cAg Antibody (C1-5): sc-23945

Hep B cAg Antibody (C1-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Hep B cAg protein of Hep B origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Hep B cAg (C1-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Hepatitis B virus (HBV), a member of the Hepadnavirus family, is known for causing serious liver inflammation, which can lead to symptoms such as vomiting, jaundice, and in severe cases, death. The core antigen (Hep B cAg) plays a crucial role in the viral life cycle as Hep B cAg encapsulates the viral genome, forming the capsid that protects the genetic material during transmission and infection. Understanding the structure and function of Hep B cAg is vital, as Hep B cAg not only aids in the diagnosis of HBV infections but also serves as a target for therapeutic interventions. The presence of Hep B cAg, along with other viral antigens like Hep B surface antigen (Hep B sAg) and e-antigen (Hep B eAg), is essential for monitoring viral replication and assessing the effectiveness of antiviral treatments. Hep B cAg and Hep B eAg are primarily utilized in clinical diagnostics, while Hep B sAg is critical for vaccine development and prevention strategies. The expression of these antigens predominantly occurs in the liver, highlighting the organ′s central role in HBV pathogenesis and the importance of targeted therapies in managing liver-related complications.

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Hep B cAg Antibody (C1-5) References:

1. In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.  |  Cao, T., et al. 2001. J Virol. 75: 11449-56. PMID: 11689626
2. HBcAg-specific cytokine production by CD4 T lymphocytes of children with acute and chronic hepatitis B.  |  Szkaradkiewicz, A., et al. 2003. Virus Res. 97: 127-33. PMID: 14602204
3. Exposure of RNA templates and encapsidation of spliced viral RNA are influenced by the arginine-rich domain of human hepatitis B virus core antigen (HBcAg 165-173).  |  Le Pogam, S., et al. 2005. J Virol. 79: 1871-87. PMID: 15650211
4. Hepatitis C virus core antigen testing: role in diagnosis, disease monitoring and treatment.  |  Tillmann, HL. 2014. World J Gastroenterol. 20: 6701-6. PMID: 24944462
5. Quantification of Antibody to Hepatitis B Core Antigen to Predict Outcomes of Patients With HBV Infection.  |  Lim, YS. 2019. Clin Gastroenterol Hepatol. 17: 39-40. PMID: 30099105
6. Virion Secretion of Hepatitis B Virus Naturally Occurring Core Antigen Variants.  |  Shih, C., et al. 2020. Cells. 10: PMID: 33396864
7. Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids.  |  Valentic, A., et al. 2023. Viruses. 16: PMID: 38275948
8. Introducing adjuvant-loaded particulate hepatitis B core antigen as an alternative therapeutic hepatitis B vaccine component.  |  Su, J., et al. 2024. JHEP Rep. 6: 100997. PMID: 38425450
9. Epitopes recognized by antibodies to denatured core protein of hepatitis B virus.  |  Bichko, V., et al. 1993. Mol Immunol. 30: 221-31. PMID: 7679466
10. Identification of hepatitis B virus core protein regions exposed or internalized at the surface of HBcAg particles by scanning with monoclonal antibodies.  |  Pushko, P., et al. 1994. Virology. 202: 912-20. PMID: 8030252
11. The structure of the variable regions of mouse monoclonal antibodies to hepatitis B virus core antigen.  |  Skrivelis, V., et al. 1993. Scand J Immunol. 37: 637-43. PMID: 8316761
12. Differentiation of core gene products of the hepatitis B virus in infected liver tissue using monoclonal antibodies.  |  Naoumov, NV., et al. 1997. J Med Virol. 53: 127-38. PMID: 9334923

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep B cAg Antibody (C1-5) has 17 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep B cAg Antibody (C1-5) Specifications

Alternate Product Name: HBcAG

Product Clone Name: C1-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 74-80

Epitope Target: Hep B cAg

Epitope Species:

Product Reactivity/Detection: an epitope corresponding to amino acids 74-80 of the core antigen

Species Reactivity/Detection: Hep B

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for Hep B cAg Antibody (C1-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin