Human Herpesvirus 6 (HHV-6) Inhibitors

Human Herpesvirus 6 (HHV-6) is a widely prevalent virus that infects most individuals during childhood, primarily causing roseola or exanthema subitum. HHV-6 exhibits a complex and dynamic signaling network that enables it to establish infection, evade host defenses, and manipulate cellular processes. The virus attaches to host cells, triggering receptor-mediated endocytosis and fusion, which facilitates viral entry into the cell. Once inside, HHV-6 modulates various cellular pathways, including immunomodulation, cell cycle control, and inflammation, to support its replication and survival. It can integrate its DNA into the host genome, leading to persistent latent infections that can reactivate under certain conditions. Understanding HHV-6 signaling is essential for developing effective antiviral strategies.

HHV-6 inhibitors play a crucial role in managing infections caused by this virus. These inhibitors target key viral processes, such as viral entry, replication, and DNA integration, to disrupt HHV-6's ability to establish infection and spread. The significance of HHV-6 inhibitors lies in their ability to impede or mitigate the complications associated with HHV-6 infections.