Hemopexin Antibody (F-12): sc-373675
- Hemopexin Antibody (F-12) is a mouse monoclonal IgG2a κ Hemopexin antibody provided at 200 µg/ml
- raised against amino acids 163-462 mapping at the C-terminus of Hemopexin of human origin
- Hemopexin Antibody (F-12) is recommended for detection of Hemopexin of human origin by WB, IP, IF and ELISA
- Anti-Hemopexin Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Hemopexin Antibody (F-12) for WB applications. These reagents are now offered in bundles with Hemopexin Antibody (F-12) (see ordering information below).
QUICK LINKS
SEE ALSO...
Hemopexin Antibody (F-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Hemopexin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Hemopexin antibody (F-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Hemopexin, also known as β 1B glycoprotein or HPX, is a 462 amino acid protein that plays a crucial role in detoxifying heme, a potentially harmful byproduct of hemoglobin and myoglobin degradation. By binding to free heme in the bloodstream, Hemopexin facilitates transport to the liver for degradation and iron recovery, thereby preventing oxidative damage and maintaining heme homeostasis. Hemopexin is primarily expressed in the liver and secreted into plasma, where Hemopexin collaborates with other proteins such as Albumin and Haptoglobin to ensure efficient clearance of toxic heme. Additionally, Hemopexin maintains metal ion homeostasis, exhibiting high affinity for metal ions like nickel, copper, cobalt, zinc, and manganese. Notably, alterations in Hemopexin levels or function can lead to pathological conditions, including minimal change disease, characterized by proteinuria and glomerular changes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hemopexin Antibody (F-12) References:
- Metal ion binding to human hemopexin. | Mauk, MR., et al. 2005. Biochemistry. 44: 1864-71. PMID: 15697212
- pH- and metal ion-linked stability of the hemopexin-heme complex. | Rosell, FI., et al. 2005. Biochemistry. 44: 1872-9. PMID: 15697213
- Identification of Amadori-modified plasma proteins in type 2 diabetes and the effect of short-term intensive insulin treatment. | Jaleel, A., et al. 2005. Diabetes Care. 28: 645-52. PMID: 15735202
- Genomic sequences encoding two types of medaka hemopexin-like protein Wap65, and their gene expression profiles in embryos. | Nakaniwa, M., et al. 2005. J Exp Biol. 208: 1915-25. PMID: 15879072
- Identification of the receptor scavenging hemopexin-heme complexes. | Hvidberg, V., et al. 2005. Blood. 106: 2572-9. PMID: 15947085
- Protease activity of plasma hemopexin. | Bakker, WW., et al. 2005. Kidney Int. 68: 603-10. PMID: 16014037
- Altered activity of plasma hemopexin in patients with minimal change disease in relapse. | Bakker, WW., et al. 2005. Pediatr Nephrol. 20: 1410-5. PMID: 16079987
- TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains. | Morrison, CJ. and Overall, CM. 2006. J Biol Chem. 281: 26528-39. PMID: 16825197
- Proteome analysis of human follicular fluid. | Angelucci, S., et al. 2006. Biochim Biophys Acta. 1764: 1775-85. PMID: 17067859
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hemopexin Antibody (F-12) | sc-373675 | 200 µg/ml | $322.00 | |||
Hemopexin Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-529535 | 200 µg Ab; 10 µg BP | $361.00 | |||
Hemopexin Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-522455 | 200 µg Ab, 40 µg BP | $361.00 | |||
Hemopexin Antibody (F-12): m-IgG2a BP-HRP Bundle | sc-547326 | 200 µg Ab; 10 µg BP | $361.00 | |||
Hemopexin Antibody (F-12) AC | sc-373675 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Hemopexin Antibody (F-12) HRP | sc-373675 HRP | 200 µg/ml | $322.00 | |||
Hemopexin Antibody (F-12) FITC | sc-373675 FITC | 200 µg/ml | $336.00 | |||
Hemopexin Antibody (F-12) PE | sc-373675 PE | 200 µg/ml | $349.00 | |||
Hemopexin Antibody (F-12) Alexa Fluor® 488 | sc-373675 AF488 | 200 µg/ml | $364.00 | |||
Hemopexin Antibody (F-12) Alexa Fluor® 546 | sc-373675 AF546 | 200 µg/ml | $364.00 | |||
Hemopexin Antibody (F-12) Alexa Fluor® 594 | sc-373675 AF594 | 200 µg/ml | $364.00 | |||
Hemopexin Antibody (F-12) Alexa Fluor® 647 | sc-373675 AF647 | 200 µg/ml | $364.00 | |||
Hemopexin Antibody (F-12) Alexa Fluor® 680 | sc-373675 AF680 | 200 µg/ml | $364.00 | |||
Hemopexin Antibody (F-12) Alexa Fluor® 790 | sc-373675 AF790 | 200 µg/ml | $364.00 |