Hec1 Antibody (1): sc-135934
- Hec1 Antibody (1) is a mouse monoclonal IgG1, cited in 4 publications, provided at 50 µg/500 µl
- raised against amino acids 495-608 of Hec1 of human origin
- recommended for detection of Hec1 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hec1 Antibody (1). This work is in progress.
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SEE ALSO...
Hec1 Antibody (1) is a mouse monoclonal IgG1 antibody that detects Hec1 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Hec1, a coiled-coil-enriched protein, plays a crucial role in the spindle checkpoint signaling pathway, which is vital for ensuring accurate chromosome segregation during cell division. Anti-Hec1 antibody (1) localizes to kinetochores during S and M phases of rapidly dividing cells, structures essential for proper alignment and separation of chromosomes. Hec1 is absent in terminally differentiated cells, making Hec1 a significant marker for tissues with high mitotic activity, such as testis, spleen, and thymus. In cancer biology, Hec1 shows elevated levels in bladder carcinoma cells during late S to M phases. Hec1 functionality is enhanced by post-translational modification; phosphorylation at Serine 165 by Nek2 is critical for maintaining chromosome segregation fidelity. Additionally, Hec1 interaction with retinoblastoma protein contributes to accurate chromosomal distribution, underscoring Hec1′s importance in both normal cellular processes and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hec1 Antibody (1) | sc-135934 | 50 µg/500 µl | $316.00 |