HEB Antibody (D-5): sc-515326
- HEB Antibody (D-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 70-89 near the N-terminus of HEB of human origin
- recommended for detection of HEB of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for HEB Antibody (D-5) for WB applications. This reagent is now offered in a bundle with HEB Antibody (D-5) (see ordering information below).
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HEB Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects HEB in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HEB, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a crucial role in regulating gene expression during muscle cell differentiation. HEB (D-5) antibody targets a protein primarily located in the nucleus, where HEB forms heterodimers with other bHLH proteins, such as Myo D, to bind to specific E box sequences in promoter regions of muscle-specific genes. Anti-HEB antibody (D-5) recognizes a protein essential for proper activation of genes necessary for muscle cell development and differentiation. HEB undergoes post-translational modifications, including phosphorylation, which can influence activity and stability, thereby impacting muscle differentiation processes. HEB monoclonal antibody (D-5) serves as an essential tool for researchers studying muscle biology and regulatory networks governing myogenic differentiation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HEB Antibody (D-5) References:
- A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. | Barndt, R., et al. 1999. J Immunol. 163: 3331-43. PMID: 10477603
- Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells. | Langerak, AW., et al. 2001. Blood. 98: 2456-65. PMID: 11588043
- The E protein HEB is preferentially expressed in developing muscle. | Conway, K., et al. 2004. Differentiation. 72: 327-40. PMID: 15554944
- Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development. | Schotte, R., et al. 2010. J Immunol. 184: 6670-9. PMID: 20483740
- Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response. | D'Cruz, LM., et al. 2012. Eur J Immunol. 42: 2031-41. PMID: 22585759
- The psychometric properties of the Hebrew version of the Memorial Symptom Assessment scale (MSAS-Heb) in patients with breast cancer. | Pud, D. 2015. J Pain Symptom Manage. 49: 790-5. PMID: 25261638
- Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells. | Rautela, J., et al. 2019. Mol Immunol. 115: 56-63. PMID: 30144957
- HeLa E-Box Binding Protein, HEB, Inhibits Promoter Activity of the Lysophosphatidic Acid Receptor Gene Lpar1 in Neocortical Neuroblast Cells. | Kim, NH., et al. 2019. Mol Cells. 42: 123-134. PMID: 30622227
- B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. | Zhuang, Y., et al. 1996. Mol Cell Biol. 16: 2898-905. PMID: 8649400
- Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene. | Di Rocco, G., et al. 1997. Mol Cell Biol. 17: 1244-53. PMID: 9032251
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HEB Antibody (D-5) | sc-515326 | 200 µg/ml | $322.00 | |||
HEB Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-541047 | 200 µg Ab; 10 µg BP | $361.00 | |||
HEB (D-5) Neutralizing Peptide | sc-515326 P | 100 µg/0.5 ml | $69.00 |